The Relationship Between Health-Related Quality of Life and Saliva C-Reactive Protein and Diurnal Cortisol Rhythm in Latina Breast Cancer Survivors and Their Informal Caregivers
A Pilot Study
Bibliographic Data
| ID | 19462007 |
|---|---|
| Authors | Thaddeus W W Pace (0000-0002-0686-1413, University of Arizona, corresponding author), Terry A Badger (0000-0002-2403-9562, University of Arizona), C Segrin (0000-0003-1797-2503, University of Arizona), Alla Sikorskii (0000-0002-4121-1627, University of Arizona), Tracy E Crane (0000-0002-4288-134X, University of Arizona Cancer Center, Tucson, AZ, USA) |
| Year | 2021 |
| Volume | 32 |
| Issue | 4 |
| Pages | 326-335 |
| Publication date | 2021-07-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Transcultural Nursing (JOURNAL) |
| Journal identifiers | ISSN: 1043-6596 • E-ISSN: 1552-7832 |
| Publisher | SAGE Publications (PUBLISHER • US) |
| DOI | 10.1177/1043659620926537 |
| PMID | 32468918 |
| OpenAlex | W3029521539 |
| Language | EN |
| References cited | 58 |
Introduction: To date, no study has explored associations between objective stress-related biomarkers (i.e., inflammatory markers, diurnal rhythm of cortisol) and health-related quality of life (HRQOL) in Latina breast cancer survivors and their informal caregivers (i.e., family, friends). Method: This cross-sectional feasibility study assessed saliva C-reactive protein, saliva diurnal cortisol rhythm (cortisol slope), and self-reported HRQOL (psychological, physical, and social domains) in 22 Latina survivor–caregiver dyads. Feasibility was defined as ≥85% samples collected over 2 days (on waking, in afternoon, and in evening). Associations between biomarkers and HRQOL were examined with correlational analyses. Results: Collection of saliva was feasible. Strongest associations were observed between survivor evening cortisol (as well as cortisol slope) and fatigue, a component of physical HRQOL. Discussion: Associations presented may help promote investigations of mechanisms linking stress-related biomarkers and HRQOL in Latina breast cancer survivor–caregiver dyads, which will facilitate development of culturally congruent interventions for this underserved group
Breast cancer · Cancer · Circadian rhythm · Evening · Psychiatry · Psychological intervention · Saliva · Cancer survivorship and care · Childhood Cancer Survivors' Quality of Life · Clinical Psychology · Health, psychology, and well-being · Medicine · Gerontology · Internal Medicine
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| Citation velocity | historical |
|---|---|
| Highly cited | No |