Drug-resistant tuberculosis in Zhejiang Province, China

An updated analysis of time trends, 1999–2013

Bibliographic Data

ID19529469
AuthorsBeibei Wu (0000-0002-4788-0469, Zhejiang Center for Disease Control and Prevention), Le Zhang (0009-0001-3593-5223, Peking University), Zhengwei Liu (0009-0003-5105-6709, Zhejiang Center for Disease Control and Prevention), Haibo He (0000-0002-5398-8169, Zhejiang Center for Disease Control and Prevention), Aizhen Pan (Zhejiang Center for Disease Control and Prevention), Fei Wang (0000-0003-0860-6317, Zhejiang Center for Disease Control and Prevention), Mingwu Zhang (0000-0001-8551-8826, Zhejiang Center for Disease Control and Prevention), Bin Chen (0000-0003-3287-934X, Zhejiang Center for Disease Control and Prevention), Zuhong Lu (0000-0003-3332-2615, Peking University), Songhua Chen (0000-0002-0858-3664, Zhejiang Center for Disease Control and Prevention), Xiaomeng Wang (0000-0002-2409-2419, Zhejiang Center for Disease Control and Prevention, corresponding author)
Year2017
Volume10
Issue1
Pages1293925-1293925
Publication date2017-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueGlobal Health Action (JOURNAL)
Journal identifiersISSN: 1654-9716 • E-ISSN: 1654-9880
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/16549716.2017.1293925
PMID28578621
OpenAlexW2621066767
LanguageEN
Citations received1
References cited16

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) hinder the progress of TB control. OBJECTIVE: To track the trend of drug-resistant tuberculosis (DR-TB) prevalence in Zhejiang Province from 1999 to 2013, and identify risk factors of resistance to second-line drugs among MDR-TB patients. DESIGN: Four DR-TB surveys had been done in Zhejiang Province in 1999, 2004, 2008 and 2013 through questionnaires, in which demographic and epidemiological items were included. After questionnaires, drug susceptibility testing (DST) targeted at four first-line drugs was done for all TB patients and DST targeted at six second-line drugs (only in 2008 and 2013) for MDR-TB patients. The drug resistance trend over time was analyzed using the Cochran-Armitage test. The factors associated with resistance to second-line drugs among MDR-TB patients were examined by a multivariate logistic regression model. RESULTS: Of 936 patients enrolled, 27 (3.21%) and 20 (21.28%) MDR-TB cases were registered as new and previously treated cases, respectively. MDR-TB showed a decreasing trend (Z = -3.31, p < 0.01) while resistance to any first-line drugs showed an increasing trend (Z = 5.22, p < 0.001), from 1999 to 2013. The highest resistance rate was shown to ofloxacin among MDR-TB patients both in 2008 (28.8%) and in 2013 (27.7%), while resistance to para-aminosalicylate decreased significantly (Z = -2.06, p = 0.04) between 2008 and 2013. MDR-TB patients aged 45-65 years (OR = 5.00, p = 0.02) were more likely to be resistant to any second-line drugs. CONCLUSIONS: DR-TB including MDR-TB remains a major public health problem in Zhejiang Province. Further efforts on MDR-TB control should be conducted to hinder drug resistance, including critical clinical use of anti-TB antibiotics and preventing transmission

China · Environmental health · Extensively drug-resistant tuberculosis · Geography · Mycobacterium tuberculosis · Traditional medicine · Tuberculosis · Infectious Diseases and Tuberculosis · Medicine · Pharmaceutical Quality and Counterfeiting · Tuberculosis Research and Epidemiology

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