Optimizing healthcare for blood donors at risk of transfusion-transmissible infections
Pre-implementation mixed methods protocol
Bibliographic Data
| ID | 19530362 |
|---|---|
| Authors | Juan Macalupu (0000-0002-2411-0277, Universidad Peruana Cayetano Heredia, corresponding author), Elsa González-Lagos (0000-0002-8543-8188, Universidad Peruana Cayetano Heredia), Steven Gimbel (0000-0003-3330-1208, University of Washington), Sarah Gimbel, Eduardo Gotuzzo (0000-0003-1747-4352, Universidad Peruana Cayetano Heredia) |
| Year | 2025 |
| Volume | 18 |
| Issue | 1 |
| Pages | 2540685-2540685 |
| Publication date | 2025-12-31 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Global Health Action (JOURNAL) |
| Journal identifiers | ISSN: 1654-9716 • E-ISSN: 1654-9880 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/16549716.2025.2540685 |
| PMID | 40791059 |
| OpenAlex | W4413108130 |
| Language | EN |
| References cited | 32 |
In the Peruvian Amazon, a significant proportion of replacement blood donors test reactive for HIV, HTLV-1/2, and other transfusion-transmissible infections but often receive no subsequent care. Optimizing healthcare for these individuals can mitigate adverse outcomes by enabling early diagnosis and management. Effective coordination between Blood Bank and Infectious Diseases services is essential to provide comprehensive care. To address this challenge, this study applies an Implementation Science approach to design and assess an innovation that enhances healthcare for blood donors affected by transfusion-transmissible infections. A pre-implementation mixed methods study will be conducted at two hospitals in the Peruvian Amazon, employing the Consolidated Framework for Implementation Research (CFIR) and a systems engineering tool (mapping). The study will focus on the inner setting domain of CFIR and map the care continuum to identify contextual determinants that may influence implementation. It has three specific aims planned for the future: first, to use a convergent mixed methods approach to examine the care continuum of blood donors and the inner settings; second, to co-design an innovation through qualitative and participatory methods, integrating Blood Bank and Infectious Diseases services via the hospital information management system; and third, to evaluate the feasibility, appropriateness, and acceptability of the co-designed innovation through a pilot. Replacement blood donation and fragmented healthcare systems are common challenges in other low- and middle-income countries. The findings of this study can inform future implementation research and policy in similar settings
Blood management · Blood transfusion · Health care · Implementation research · Medical emergency · Psychological intervention · Global Public Health Policies and Epidemiology · Health Policy Implementation Science · Medicine · Mosquito-borne diseases and control · Nursing
The updated Consolidated Framework for Implementation Research based on user feedback
The Adapt-ITT Model
Making sense of implementation theories, models and frameworks
Implementation strategies
Guidance on how to develop complex interventions to improve health and healthcare
Psychometric assessment of three newly developed implementation outcome measures
Better reporting of interventions
Fostering implementation of health services research findings into practice
Research electronic data capture (Redcap)—A metadata-driven methodology and workflow process for providing translational research informatics support
Stakeholder analysis in health innovation planning processes
Healthcare and Health Problems from the Perspective of Indigenous Population of the Peruvian Amazon
Kaniuwatewara (when we get sick)
Sample sizes for saturation in qualitative research
Designing and Conducting Mixed Methods Research
| Highly cited | No |
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