Depressive symptoms of female nursing staff working in stressful environments and their association with serum creatine kinase and lactate dehydrogenase – a preliminary study
Bibliographic Data
| ID | 19536606 |
|---|---|
| Authors | Ayako Kato (0009-0002-8785-9186, University of Shizuoka), Hiroyuki Sakakibara (0000-0003-4497-1311, University of Shizuoka), Hirohito Tsuboi (0000-0001-5986-8523, Kanazawa University), Asami Tatsumi (Hamamatsu University School of Medicine), Masanobu Akimoto, Kayoko Shimoi (0000-0003-4565-6233, University of Shizuoka), Takeshi Ishii (University of Shizuoka), Hiroshi Kaneko (0000-0002-7861-5086, Fujita Health University), Tsutomu Nakayama (Nippon Veterinary and Life Science University), Norio Ohashi (0000-0003-3465-1058, University of Shizuoka, corresponding author) |
| Year | 2014 |
| Volume | 8 |
| Issue | 1 |
| Pages | 21-21 |
| Publication date | 2014-12-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | BioPsychoSocial Medicine (JOURNAL) |
| Journal identifiers | ISSN: 1751-0759 • E-ISSN: 1751-0759 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1186/1751-0759-8-21 |
| PMID | 25243019 |
| PMCID | PMC4169250 |
| OpenAlex | W2166023696 |
| Language | EN |
| Citations received | 2 |
| References cited | 13 |
BACKGROUND: The activity of creatine kinase (CK) in serum has recently been reported to be potentially associated with several types of depression. The aim of this study is to evaluate whether serum enzymes, including CK, vary even in a healthy population with depressive symptoms caused by work-related stress. We gave questionnaires and blood examinations to 93 healthy female nursing home workers and did an enzyme-linked immunosorbent assay for the quantitative detection of CK isozyme muscle-type M chain (CK-MM) in serum. FINDINGS: Depressive symptoms were determined using the Center for Epidemiologic Studies Depression (CES-D) scale and compared with the results of the blood examination and serum CK-MM levels. The CES-D results showed significant negative correlations with total CK and lactate dehydrogenase (LDH) activities and CK-MM level (r = -0.29, p = 0.0062; r = -0.29, p = 0.0065; r = -0.33, p = 0.0016, respectively). CONCLUSIONS: Total CK and LDH activities and serum CK-MM level appear to be associated with the depressive symptoms of healthy nurses working in stressful environments, although the significance level was relatively low. The simultaneous detection of serum CK and LDH activities or serum CK-MM level and LDH activity may be useful as an indicator of depressive symptoms, at least for female nursing staff with work-related stress
Biology · Cognition · Creatine kinase · Depressive symptoms · Enzyme · Lactate dehydrogenase · Psychiatry · Psychosomatic medicine · Psychotherapist · Cardiac Health and Mental Health · Clinical Psychology · Exercise and Physiological Responses · Medicine · Nursing · Psychology · Treatment of Major Depression · Biochemistry · Internal Medicine
| Citations per year | 0.18 |
|---|---|
| Citation span | 2015 - 2021 (7) |
| Highly cited | No |