Depressive symptoms are associated with oxidative stress in middle-aged women
A cross-sectional study
Bibliographic Data
| ID | 19536737 |
|---|---|
| Authors | Asuka Hirose (0000-0003-2731-4790, Tokyo Medical and Dental University), Masakazu Terauchi (0000-0001-5577-0094, Tokyo Medical and Dental University, corresponding author), Mihoko Akiyoshi (Tokyo Medical and Dental University), Yoko Owa (Tokyo Medical and Dental University), Kiyoko Kato (0000-0003-0047-7637, Tokyo Medical and Dental University), Toshiro Kubota (Tokyo Medical and Dental University) |
| Year | 2016 |
| Volume | 10 |
| Issue | 1 |
| Pages | 12-12 |
| Publication date | 2016-12-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | BioPsychoSocial Medicine (JOURNAL) |
| Journal identifiers | ISSN: 1751-0759 • E-ISSN: 1751-0759 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1186/s13030-016-0066-4 |
| PMID | 27118992 |
| OpenAlex | W2342711490 |
| Language | EN |
| Citations received | 2 |
| References cited | 39 |
BACKGROUND: Oxidative stress is known to be a factor in various diseases. In this study, we investigated whether physical and psychological symptoms of menopause, cardiovascular parameters, body composition, and lifestyle factors are associated with oxidative stress in middle-aged women. METHODS: This cross-sectional study used baseline data collected in a previous study that examined the effects of a dietary supplement on a variety of health parameters in 95 women aged 40 to 60 years. Participants had been assessed for age, menopausal status, body composition, cardiovascular parameters, physical and psychological symptoms of menopause, and lifestyle factors. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) level, an oxidative stress marker, had also been measured. Dichotomizing 8-OHdG levels as low (≤25 ng/mg creatinine) and high (>25 ng/mg creatinine), we sought to identify the health parameters that are associated with high 8-OHdG level. RESULTS: Women with a high 8-OHdG level had lower body weight, lower body mass index, lower body fat mass, higher body temperature, scored higher for both anxiety and depression on the Hospital Anxiety and Depression Scale (HADS), and consumed more alcohol. Multiple logistic regression analysis revealed that the HADS-depression subscale (HADS-D) score was the sole independent contributor to high 8-OHdG level (adjusted odds ratio, 1.23 per point increase in HADS-D score; 95 % confidence interval, 1.06-1.45). CONCLUSION: Depressive symptom score was shown to be independently associated with high 8-OHdG level in middle-aged women, suggesting a link between mood disorder and oxidative stress. TRIAL REGISTRATION: UMIN-CTR UMIN000009353
Anxiety · Body mass index · Creatinine · Cross-sectional study · Hospital Anxiety and Depression Scale · Menopause · Odds ratio · Oxidative stress · Pathology · Psychiatry · Antioxidant Activity and Oxidative Stress · Medicine · Skin Protection and Aging · Tryptophan and brain disorders · Internal Medicine
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Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression
Depression and Oxidative Stress
| Citations per year | 0.25 |
|---|---|
| Citation span | 2018 - 2019 (2) |
| Highly cited | No |