Evaluation of the Efficacy and Safety of On-Demand Tadalafil Alone or Combined With Lidocaine Spray for Treating Patients With Comorbid Erectile Dysfunction and Premature Ejaculation
A Randomized Controlled Trial
Bibliographic Data
| ID | 19543155 |
|---|---|
| Authors | Min Liu (0000-0002-6622-5486, First Affiliated Hospital of Gannan Medical University), Zi Xiang Deng (0009-0003-7042-7165, First Affiliated Hospital of Gannan Medical University, corresponding author), Xianxiang Zhu (0009-0000-7376-6187), Xian-Xiang Zhu (First Affiliated Hospital of Gannan Medical University), Shian Hu (0009-0001-0592-8153, Gannan Medical University) |
| Year | 2025 |
| Volume | 37 |
| Issue | 1 |
| Pages | 60-68 |
| Publication date | 2025-01-02 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Sexual Health (JOURNAL) |
| Journal identifiers | ISSN: 1931-7611 • E-ISSN: 1931-762X |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/19317611.2024.2420048 |
| PMID | 39935900 |
| OpenAlex | W4404221541 |
| Language | EN |
| References cited | 30 |
Background To evaluate the efficacy and safety of on-demand 20 mg tadalafil alone or combined with lidocaine spray for treating patients with comorbid erectile dysfunction (ED) and premature ejaculation (PE).Methods This randomized controlled trial included 98 patients with comorbid ED and PE, randomly assigned to the experimental group (n = 50, tadalafil alone) or the active control group (n = 48, tadalafil combined with lidocaine spray). Patients took tadalafil 30 min before sexual intercourse, while the combination therapy group also used lidocaine spray 5 min before intercourse. After 12 weeks of treatment, changes in the International Index of Erectile Function (IIEF-5), Chinese Index of Premature Ejaculation (CIPE-5), Intravaginal Ejaculatory Latency Time (IELT), and Sexual Satisfaction Score (SSS) were evaluated.Results Both groups showed significant improvement in IIEF-5 scores, but the difference between groups was not significant (F = 0.89, p = 0.45). The active control group showed significant improvement in CIPE-5 scores (p 0.05). IELT in the active control group increased significantly from 25.7 s to 198.6 s (Z = 6.03, p 0.05). The incidence of adverse events was similar in both groups (14% vs 20.8%, p = 0.575).Conclusion Tadalafil combined with lidocaine spray is superior to tadalafil alone in improving symptoms, prolonging IELT, and enhancing sexual satisfaction in patients with comorbid ED and PE, with comparable safety. This combination therapy provides a new approach for improving treatment strategies for patients with comorbid ED and PE. Large-scale, multi-center randomized controlled trials are needed to further validate these findings
Anesthesia · Ejaculation · Erectile dysfunction · Lidocaine · On demand · Premature ejaculation · Randomized controlled trial · Tadalafil · Medicine · Pharmaceutical Quality and Counterfeiting · Psychology · Sexual function and dysfunction studies · Sexuality, Behavior, and Technology · Internal Medicine · Urology
| Citation velocity | historical |
|---|---|
| Highly cited | No |