Association between tuberculosis and psychotic experiences
Mediating factors and implications for patient care in low- and middle-income countries
Bibliographic Data
| ID | 19550940 |
|---|---|
| Authors | Anna Monistrol-Mula (0000-0001-5879-3558, Instituto de Salud Carlos III), Mireia Félez-Nóbrega (0000-0002-3484-4119, Instituto de Salud Carlos III), Hans Oh (0000-0002-8458-8723, University of Southern California), Josep Maria Haro (0000-0002-3984-277X, Instituto de Salud Carlos III), Ai Koyanagi (0000-0002-9565-5004, Instituto de Salud Carlos III) |
| Year | 2024 |
| Volume | 14 |
| Pages | 04005-04005 |
| Publication date | 2024-03-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Global Health (JOURNAL) |
| Journal identifiers | ISSN: 2047-2978 • E-ISSN: 2047-2986 |
| Publisher | International Society of Global Health (PUBLISHER • GB) |
| DOI | 10.7189/jogh.14.04005 |
| PMID | 38419459 |
| OpenAlex | W4392287670 |
| Language | EN |
| Citations received | 2 |
| References cited | 48 |
Background: Tuberculosis may play a role in the aetiology of psychosis. However, little is known about the association between tuberculosis and psychotic experiences (PEs) or the mediating factors of this association. Methods: We analysed cross-sectional data from 48 low- and middle-income countries of the World Health Survey (WHS). Tuberculosis assessment was based on past 12-month symptoms of active tuberculosis. We assessed four types of past 12-month PEs with the Composite International Diagnostic Interview. We performed multivariable multinomial logistic regression and mediation analysis. Results: We analysed data on 224 842 individuals aged ≥18 years (mean age = 38.3 years, standard deviation = 16.0; 50.7% women). Tuberculosis was associated with 1.84 (95% confidence interval (CI) = 1.41-2.40), 2.18 (95%CI = 1.58-3.03), and 3.79 (95%CI = 2.88-4.98) times higher odds for 1, 2, and ≥3 PEs, respectively. The mediation analysis showed that the association between tuberculosis and at least one PE is mainly explained by anxiety (31.5%), sleep/energy (27.8%), and pain/discomfort (23.5%). Conclusions: Tuberculosis was associated with increased odds of PEs. Factors such as affect, sleep, and pain should be considered in tuberculosis patients to target those who might be particularly vulnerable to PEs, and consequently, to psychotic disorders and other adverse effects of PE
Anxiety · Confidence interval · Cross-sectional study · Mediation · Odds ratio · Pathology · Psychiatry · Tuberculosis · Bipolar Disorder and Treatment · Clinical Psychology · Medicine · Psychology · Schizophrenia research and treatment · Tryptophan and brain disorders · Internal Medicine
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On the Interactions of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Sleep
The World Mental Health (WMH) Survey Initiative version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI)
Sleep quality and its associated factors among patients with tuberculosis
Association between depression or anxiety symptoms and immune-inflammatory characteristics in in-patients with tuberculosis
Health Conditions and Psychotic Experiences
Cognitive-behavioral therapy on psychological stress and quality of life in subjects with pulmonary tuberculosis
Total, Direct, and Indirect Effects in Logit and Probit Models
| Citations per year | 2 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |