A multicenter survey of asymptomatic cryptococcal antigenemia among patients with advanced HIV disease in Nigeria
Bibliographic Data
| ID | 19590703 |
|---|---|
| Authors | Rita Oladele (0000-0003-1488-3345, University of Lagos, corresponding author), Alexander M Jordan (0000-0002-7834-866X, Waterborne Environmental (United States), corresponding author), Joy U Okaa (0000-0002-8246-3521, Nnamdi Azikiwe University, corresponding author), Iriagbonse I Osaigbovo (0000-0001-8111-0743, University of Benin Teaching Hospital, corresponding author), Shuwaram A Shettima (0000-0002-4706-4293, Modibbo Adama University of Technology, corresponding author), Nathan Y Shehu (0000-0001-8802-4928, Jos University Teaching Hospital, corresponding author), Adeyinka A Davies (0000-0002-6849-1315, Olabisi Onabanjo University Teaching Hospital, corresponding author), Yahaya Mohammed (0000-0003-0075-9511, Usmanu Danfodiyo University, corresponding author), Mary A Alex-Wele (0000-0001-9811-4337, University of Port Harcourt Teaching Hospital, corresponding author), Garba Iliyasu (0000-0001-8449-4674, Bayero University Kano, corresponding author), Jude C Nwaokenye (0000-0003-4877-5588, University College Hospital, Ibadan, corresponding author), Samuel A Fayemiwo (0000-0001-8937-3353, University College Hospital, Ibadan, corresponding author), Ubong A Udoh (0000-0002-7673-2414, University of Calabar, corresponding author), Titilola Gbaja‐Biamila (0000-0003-2958-2924, Nigerian Institute of Medical Research, corresponding author), David W Denning (0000-0001-5626-2251, Manchester Academic Health Science Centre, corresponding author), Tom M Chiller, Tom Chiller (0000-0002-2251-8033, Waterborne Environmental (United States), corresponding author) |
| Editors | Andrés F Henao-Martínez |
| Year | 2023 |
| Volume | 3 |
| Issue | 1 |
| Pages | e0001313 |
| Publication date | 2023-01-31 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0001313 |
| PMID | 36963010 |
| OpenAlex | W4318698413 |
| Language | EN |
| Citations received | 1 |
| References cited | 21 |
As of 2018, cryptococcal antigen (CrAg) screening in patients with advanced human immunodeficiency virus (HIV) disease (AHD) was not routinely implemented in Nigeria despite being recommended in the national HIV treatment guidelines. Our aim was to determine the prevalence and risk factors for asymptomatic cryptococcal antigenemia in adult people living with HIV (PLHIV) in Nigeria to advocate for the implementation of routine CrAg screening. A descriptive cross-sectional study and CrAg screening of consecutive adult PLHIV with CD4 counts ≤200 cells/ μ L was conducted from April 2018 to April 2019 at HIV clinics in eleven tertiary hospitals spread across Nigeria’s six geopolitical regions. Prevalence of asymptomatic cryptococcal antigenemia was estimated by facility and geopolitical zone. Logistic regression was conducted to identify risk factors for cryptococcal antigenemia. In total, 1,114 patients with AHD were screened. The overall prevalence of asymptomatic cryptococcal antigenemia was 3.9% with wide variation across facilities (range: 0/75 [0%]– 15/122 [12.3%]) and geopolitical zones (range: 0/75 [0%]–19/279 [6.8%]). Prevalence of antigenemia was highest in the South-West (19/279 [6.8%]) and lowest in the North-East (0/75 [0%]). Prevalence was 5.2% (26/512) and 3.2% (18/561) in patients with CD4
Asymptomatic · Cross-sectional study · Disease · Logistic regression · Pathology · Antifungal resistance and susceptibility · Fungal Infections and Studies · Medicine · Nail Diseases and Treatments · Immunology · Internal Medicine
| Citations per year | 0.5 |
|---|---|
| Citation span | 2024 - 2024 (1) |
| Highly cited | No |