Interferon-based agents for current and future viral respiratory infections
A scoping literature review of human studies
Bibliographic Data
| ID | 19590990 |
|---|---|
| Authors | Aldina Mešić (0000-0001-6425-3777, University of Washington, corresponding author), Emahlea K Jackson (0000-0002-3067-647X, University of Washington), Mathias Lalika (0000-0003-0229-9942, University of Washington), David M Koelle (0000-0003-1255-9023, University of Washington), Rena C Patel (0000-0001-9893-5856, University of Washington) |
| Editors | Muhammad Asaduzzaman (0000-0001-9048-7980) |
| Year | 2022 |
| Volume | 2 |
| Issue | 4 |
| Pages | e0000231 |
| Publication date | 2022-04-06 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0000231 |
| PMID | 36962150 |
| OpenAlex | W4225991471 |
| Language | EN |
| References cited | 59 |
The interferon (IFN) system is a potent line of defense against viral infections. IFN-based agents already tested may be of use in COVID-19 or future viral respiratory outbreaks. Here we review the comparative efficacy, safety/tolerability, and future potential of IFN-based therapeutics. We reviewed human studies in which IFN or IFN pathway-interacting agents were used for viral respiratory infections. We identified 977 articles, of which 194 were included for full-text review. Of these, we deemed 35 articles to be relevant. The use of IFN-based agents for pre-exposure prophylaxis (n = 19) and treatment (n = 15) were most common, with intranasal (n = 22) as the most common route. We found IFN-α (n = 23) was used most often, and rhinovirus (n = 14) was the most common causative agent. Studies demonstrated mixed efficacy but generally positive safety and tolerability. Host-directed therapies, such as IFN or IFN inducers, are worthy of additional research to target viral respiratory infections lacking direct-acting antivirals
Adverse effect · Interferon · Respiratory system · Rhinovirus · Tolerability · Virus · Immune Cell Function and Interaction · interferon and immune responses · Medicine · Respiratory viral infections research · Immunology · Internal Medicine · Pharmacology · Virology
| Highly cited | No |
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