Association between HTLV-1/2 infection and Covid-19 severity in a migrant Shipibo-Konibo population in Lima, Peru
Bibliographic Data
| ID | 19591050 |
|---|---|
| Authors | Fátima Avila Dextre (0000-0002-0632-508X, Universidad Peruana Cayetano Heredia), Bryan Morales Álvarez (Universidad Peruana Cayetano Heredia), Paulo Aguirre Castañeda, Paulo Castañeda (0009-0005-0450-0349, Universidad Peruana Cayetano Heredia), Isaac Efrain Alva, Giovanni López (Universidad Peruana Cayetano Heredia), Alvaro Schwalb (0000-0002-6518-9719, Universidad Peruana Cayetano Heredia), Eduardo Gotuzzo (0000-0003-1747-4352, Universidad Peruana Cayetano Heredia, corresponding author) |
| Editors | Charin Modchang (0000-0002-0739-006X) |
| Year | 2024 |
| Volume | 4 |
| Issue | 7 |
| Pages | e0003442 |
| Publication date | 2024-07-10 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0003442 |
| PMID | 38985713 |
| OpenAlex | W4400489852 |
| Language | EN |
| References cited | 21 |
Objectives The migrant community of the Shipibo-Konibo indigenous people in Lima, Peru were extremely vulnerable during the COVID-19 pandemic. Additionally, infection with human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in this population causing immunosuppression. The aim of the study was to describe the association between HTLV-1/2 infection and the clinical severity of COVID-19. Methods This was a cross-sectional descriptive study involving a survey of adult Shipibo-Konibo indigenous migrants residing in Cantagallo-Rímac who were identified as suspected or confirmed cases of COVID-19. Blood samples were collected for SARS-CoV-2 antibody and HTLV-1/2 ELISA testing. A confirmatory Western Blot test was performed for those with a positive ELISA test. Results A total of 182 individuals were surveyed and sampled. No significant association was found between HTLV-1/2 infection and the clinical severity of COVID-19. The prevalence of HTLV-1/2 was 8.8% (95%CI: 5.0–14.1) with Western Blot. Age was the only statistically significant risk factor for developing a more severe form of COVID-19 (OR: 1.03; 95%CI: 1.00–1.06; p = 0.032). Conclusions There was no association found between HTLV-1/2 infection and the clinical severity of COVID-19. The prevalence of HTLV-1/2 infection in the Shipibo-Konibo population is high and warrants continuous monitoring in the advent of other infectious disease outbreaks and the development of HTLV-associated comorbidities
Biology · Cross-sectional study · Disease · Environmental health · Immunosuppression · Indigenous · Outbreak · Pandemic · Pathology · Population · Animal Disease Management and Epidemiology · Demography · Leptospirosis research and findings · Medicine · T-cell and Retrovirus Studies · Immunology · Internal Medicine · Virology
| Highly cited | No |
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