Quality of care and post-discharge morbidity among children diagnosed with severe malaria in rural Uganda
A prospective cohort study
Bibliographic Data
| ID | 19591192 |
|---|---|
| Authors | Jennifer M Kniss (0009-0003-0519-5345, University of North Carolina at Chapel Hill, corresponding author), Georget Kibaba (corresponding author), Emmanuel Baguma (corresponding author), Sujata Bhattarai Chhetri (0009-0006-0623-9380, University of North Carolina at Chapel Hill, corresponding author), Cate Hendren (University of Massachusetts Chan Medical School, corresponding author), Moses Ntaro (0000-0001-7944-4082, Mbarara University of Science and Technology, corresponding author), Edgar Mulogo (0000-0003-3859-453X, Mbarara University of Science and Technology, corresponding author), Samson Karabyo (corresponding author), Ross M Boyce (0000-0002-9489-6324, University of North Carolina at Chapel Hill, corresponding author) |
| Editors | Amy Kristine Bei |
| Year | 2024 |
| Volume | 4 |
| Issue | 10 |
| Pages | e0003794 |
| Publication date | 2024-10-07 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0003794 |
| PMID | 39374246 |
| OpenAlex | W4403183784 |
| Language | EN |
| References cited | 26 |
Pediatric severe malaria is a significant contributor of morbidity and mortality in Uganda. Most information is derived from tertiary referral centers and urban centers. Little is known about routine care or post-discharge outcomes in rural areas. We conducted a longitudinal cohort study of pediatric severe malaria at St. Paul’s Level IV Health Center (SPHC) in Kasese, Uganda. We collected demographic, clinical, and laboratory results, and conducted follow-up 14 days post-discharge to assess patient outcomes in the immediate post-discharge period. The initial cohort included 187 children aged 0 to 17 years enrolled between July 9th, 2023 and January 9th, 2024. Almost all (94.7%) participants had a parasitological confirmed malaria diagnosis by rapid diagnostic tests or blood smear. While at SPHC, 95.7% of patients received 3+ doses of intravenous Artesunate, and 92.0% also received oral antimalarials. 62.0% had at least one symptom of severe malaria, with altered consciousness (40.6%) and convulsions (29.9%) the most frequently reported. 26.1% had evidence of severe malarial anemia (Hb
Anemia · Artesunate · Cohort · Cohort study · Family medicine · Malaria · Nausea · Plasmodium falciparum · Prospective cohort study · Referral · Malaria Research and Control · Medicine · Mosquito-borne diseases and control · Parasites and Host Interactions · Internal Medicine · Pediatrics · Surgery
| Highly cited | No |
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