Outborn newborns drive birth asphyxia mortality rates—An 8 year analysis at a rural level two nursery in Uganda
Bibliographic Data
| ID | 19592020 |
|---|---|
| Authors | Anna B Hedstrom (0000-0002-3269-1892, University of Washington, corresponding author), James Nyonyintono (Kiwoko Hospital), Paul Mubiri (0000-0002-2259-3455, Makerere University), Hilda Namakula Mirembe, Brooke Magnusson (0000-0002-0533-518X), Josephine Nakakande (Kiwoko Hospital), Molly MacGuffie, Mushin Nsubuga (Kiwoko Hospital), Peter Waiswa (0000-0001-8221-902X, Makerere University), Harriet Nambuya (0000-0002-6220-0935, Jinja Hospital), Maneesh Batra (0000-0003-0421-4332, University of Washington) |
| Editors | Julia Robinson (0000-0003-0719-3995) |
| Year | 2023 |
| Volume | 3 |
| Issue | 11 |
| Pages | e0002261 |
| Publication date | 2023-11-08 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0002261 |
| PMID | 37939037 |
| OpenAlex | W4388487944 |
| Language | EN |
| References cited | 40 |
Birth asphyxia is a leading cause of global neonatal mortality. Most cases occur in low- and middle- income countries and contribute to half of neonatal deaths in Uganda. Improved understanding of the risk factors associated with mortality among these patients is needed. We performed a retrospective cohort study of a clinical database and report maternal demographics, clinical characteristics and outcomes from neonates with birth asphyxia at a Ugandan level two unit from 2014 through 2021. “Inborn” patients were born at the hospital studied and “outborn” were born at another facility or home and then admitted to the hospital studied. Doctors assigned the patient’s primary diagnosis at death or discharge. We performed a Poisson model regression of factors associated with mortality among patients with asphyxia. The study included 1,565 patients with birth asphyxia and the proportion who were outborn rose from 26% to 71% over eight years. Mortality in asphyxiated patients increased over the same period from 9% to 27%. Factors independently associated with increased death included outborn birth location (ARR 2.1, p 8.3 mmol/L (RR 1.7, p 60bpm was protective against death (ARR 0.6, p
Asphyxia · Case fatality rate · Cohort · Confidence interval · Mortality rate · Obstetrics · Poisson regression · Population · Referral · Relative risk · Retrospective cohort study · Infant Development and Preterm Care · Medicine · Neonatal and fetal brain pathology · Neonatal Respiratory Health Research · Epidemiology · Internal Medicine · Pediatrics
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| Citation velocity | historical |
|---|---|
| Highly cited | No |