Laboratory readiness and genomic surveillance of Covid-19 in the capital of Brazil

Dados Bibliográficos

ID19592978
AutoresFrancisca Verônica Cavalcante (0000-0002-8706-0457, Universidade de Brasília, autor correspondente), Christina Pacheco Santos Martins (0000-0003-1829-1515, Universidade Federal da Paraíba, autor correspondente), Christina Pacheco Santos Martin, Gustavo Saraiva Frio (0000-0001-6453-312X, Pontifícia Universidade Católica do Rio Grande do Sul, autor correspondente), Rodrigo Stabeli (0000-0002-0476-920X, Fundação Oswaldo Cruz, autor correspondente), Rodrigo Guerino Stabeli, Leonor Maria Pacheco Santos (0000-0002-6739-6260, Universidade de Brasília, autor correspondente)
EditoresSyed Shahid Abbas
Ano2025
Volume5
Fascículo1
Páginase0003289
Data de publicação2025-01-09
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoPLOS Global Public Health (JOURNAL)
Identificadores do periódicoISSN: 2767-3375 • E-ISSN: 2767-3375
EditoraPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0003289
PMID39787152
OpenAlexW4406230836
IdiomaEN
Referências citadas16

This study aims to analyze the diagnostic readiness to Covid-19 and the genomic surveillance of SARS-CoV-2 in Brasília, the capital of Brazil. This is a retrospective, cross-sectional study, with data from: cases/deaths—Ministry of Health; RT-PCR analyses Brasília Central Public Health Laboratory (LACEN); genomics—Global Initiative on Sharing All Influenza Data (GISAID). It was found that in March 2021, with the Gamma variant was predominant, RT-PCR diagnostic tests administered by LACEN reached their peak, followed by a reduction, possibly due to the start of vaccination. New peaks were observed in September 2021 and January 2022. The average time for releasing RT-PCR results was reduced from eight days (July 2020), to around eight hours in 2023. The participation of private laboratories was evident in sequencing the SARS-CoV-2 variants of concern in Brasília (n = 1,897). LACEN sequenced 50% of the samples received (571). A decrease in the incidence of cases and deaths due to Covid-19 was noted in the years 2022 to 2023, following the national trend. LACEN maintained RT-PCR diagnostic tests administered satisfactorily throughout the period. Regarding the genomic surveillance of SARS-CoV-2, the vast majority of samples were sequenced by private laboratories when compared to the public laboratory

Christian ministry · Disease · Environmental health · Pathology · Political science · Public health · Public health surveillance · Veterinary medicine · Demography · Medicine · SARS-CoV-2 and COVID-19 Research · SARS-CoV-2 detection and testing · Viral Infections and Outbreaks Research · Internal Medicine