Evaluating operational parameters of the careHPV, GeneXpert, AmpFire, and MA-6000 HPV systems for cervical precancer screening
Experience from Battor, Ghana
Bibliographic Data
| ID | 19593140 |
|---|---|
| Authors | Kofi Effah (0000-0003-1216-2296, Catholic University College of Ghana, corresponding author), Comfort Mawusi Wormenor (Catholic University College of Ghana, corresponding author), Ethel Tekpor (Catholic University College of Ghana, corresponding author), Joseph Emmanuel Amuah (University of Ottawa, corresponding author), Nana Owusu Mensah Essel (0000-0001-5494-5411, University of Alberta, corresponding author), Isaac Gedzah (Catholic University College of Ghana, corresponding author), Seyram Kemawor (0000-0002-4043-3236, Catholic University College of Ghana, corresponding author), Benjamin Tetteh Hansen (Catholic University College of Ghana, corresponding author), Bernard Hayford Atuguba (Catholic University College of Ghana, corresponding author), Gifty Belinda Klutsey (Catholic University College of Ghana, corresponding author), Edna Sesenu (Catholic University College of Ghana, corresponding author), Stephen Danyo (Catholic University College of Ghana, corresponding author), Patrick Kafui Akakpo (0000-0003-0356-0663, University of Cape Coast, corresponding author) |
| Editors | Natalia M Rodríguez (0000-0002-2633-4397) |
| Year | 2023 |
| Volume | 3 |
| Issue | 8 |
| Pages | e0001639 |
| Publication date | 2023-08-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0001639 |
| PMID | 37624774 |
| OpenAlex | W4386169554 |
| Language | EN |
| Citations received | 3 |
| References cited | 28 |
In response to calls by the World Health Organization for cervical precancer screening services in low-resource settings to lean toward HPV DNA testing, a number of testing platforms have been made available. This study aimed to evaluate the operational parameters of four HPV testing systems in previous ( care HPV) and current (GeneXpert, AmpFire, and MA-6000) use in a secondary healthcare setting in terms of ‘appropriateness’, ease of use, throughput, and diagnostic yield. This descriptive retrospective cohort analysis included 6056 women who presented to our facility between June 2016 and March 2022 for cervical precancer screening via HPV testing. A large majority of this cohort underwent AmpFire testing (55.8%), followed by care HPV (23.3%), MA-6000 (14.7%), and GeneXpert (6.1%). MA-6000 showed the highest hr-HPV positivity rate of 26.4% (95% CI, 23.6–29.5), followed by AmpFire (17.2%; 95% CI, 15.9–17.5). GeneXpert and care HPV showed similar hr-HPV positivity rates of 14.8% (95% CI, 11.3–18.8) and 14.8% (95% CI, 13.0–16.8), respectively. For the AmpFire and MA-6000 platforms, which utilize similar detection and reporting formats, we found a significant excess detection rate of 9.2% (95% CI, 6.1–12.4; p -value other hr-HPV types (both p -values
Biology · Cohort · Dna testing · GeneXpert MTB/RIF · Gynecology · Obstetrics · Pathology · Retrospective cohort study · Tuberculosis · Cervical Cancer and HPV Research · Global Cancer Incidence and Screening · Medicine · Internal Medicine
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| Unique citing works | 3 |
|---|---|
| Citations per year | 3 |
| Citation span | 2025 - 2026 (2) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 3 |