Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children’s hospital

Bibliographic Data

ID19593783
AuthorsNguyen Duc Toan (0000-0003-0904-9807, Pham Ngoc Thach University of Medicine), Thomas C Darton (0000-0003-2209-9956, University of Sheffield), Nguyen Hoang Thien Huong (0000-0001-6096-4029, Vietnam National University Ho Chi Minh City), Le Thanh Hoang Nhat (0000-0002-3756-7217, Oxford University Clinical Research Unit), To Nguyen Thi Nguyen (Oxford University Clinical Research Unit), Ha Thanh Tuyen (Oxford University Clinical Research Unit), Le Quoc Thinh (Children's Hospital 1), Nguyen Kien Mau (Children's Hospital 1), Pham Thi Thanh Tam (Oxford University Clinical Research Unit), Cam Ngoc Phuong, Le Nguyen Thanh Nhan (0000-0002-5405-7198, Oxford University Clinical Research Unit), Ngo Ngoc Quang Minh (Children's Hospital 1), Ngo Minh Xuan (0000-0002-5971-5022, Pham Ngoc Thach University of Medicine), Tang Chi Thuong (0000-0002-8223-696X, Pham Ngoc Thach University of Medicine), Nguyen Thanh Hung (0009-0009-7871-8374, Vietnam National University Ho Chi Minh City), Christine Boinett, Christine J Boinett (0000-0001-5289-8674, Wellcome Sanger Institute), Stephen Reece, Stephen T Reece (0000-0003-0725-6271, Kymab (United Kingdom)), Abhilasha Karkey (0000-0002-5179-650X), Jeremy N Day (0000-0002-7843-6280, University of Oxford), Stephen Baker (0000-0003-1308-5755, University of Cambridge, corresponding author)
EditorsPaddy Ssentongo (0000-0003-1565-5731)
Year2022
Volume2
Issue9
Pagese0000875
Publication date2022-09-02
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePLOS Global Public Health (JOURNAL)
Journal identifiersISSN: 2767-3375 • E-ISSN: 2767-3375
PublisherPublic Library of Science (PLoS) (PUBLISHER)
DOI10.1371/journal.pgph.0000875
PMID36962870
OpenAlexW4294316771
LanguageEN
References cited45

Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there are limited contemporaneous data linking the clinical features of neonatal sepsis with outcome in LMICs. Here, we aimed to identify factors associated with mortality from neonatal sepsis in Vietnam. We conducted a prospective, observational study to describe the clinical features, laboratory characteristics, and mortality rate of neonatal sepsis at a major children’s hospital in Ho Chi Minh City. All in-patient neonates clinically diagnosed with probable or culture-confirmed sepsis meeting inclusion criteria from January 2017 to June 2018 were enrolled. We performed univariable analysis and logistic regression to identify factors independently associated with mortality. 524 neonates were recruited. Most cases were defined as late-onset neonatal sepsis and were hospital-acquired (91.4% and 73.3%, respectively). The median (IQR) duration of hospital stay was 23 (13–41) days, 344/524 (65.6%) had a positive blood culture (of which 393 non-contaminant organisms were isolated), and 69/524 (13.2%) patients died. Coagulase-negative staphylococci (232/405; 57.3%), Klebsiella spp. (28/405; 6.9%), and Escherichia coli (27/405; 6.7%) were the most isolated organisms. Sclerema (OR = 11.4), leukopenia 3 (OR = 7.8), thrombocytopenia 3 (OR = 3.7), base excess 4 mmol/L (OR = 3.4), extremely low birth weight (OR = 3.2), and hyperglycaemia >180 mg/dL (OR = 2.6) were all significantly ( p

Bacteremia · Blood culture · Logistic regression · Low birth weight · Mortality rate · Neonatal sepsis · Pregnancy · Sepsis · Medicine · Neonatal and Maternal Infections · Neonatal Respiratory Health Research · Sepsis Diagnosis and Treatment · Internal Medicine · Pediatrics

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