Impact of a Cryptococcal meningitis diagnosis and treatment program at Lira Regional Referral Hospital in rural, Northern Uganda
Bibliographic Data
| ID | 19594023 |
|---|---|
| Authors | Abigail Link (0000-0003-2209-1946, University of Washington), Mark Okwir (0000-0001-8452-313X, Lira Hospital), David B Meya (0000-0002-8854-0321, Infectious Diseases Institute), David Meya, Betty Nabongo (Lira Hospital), James Okello (0000-0003-2634-3063, Lira Hospital), Danuta Kasprzyk (0000-0002-3741-7761, University of Washington), Paul R Bohjanen (0000-0002-2772-3597, University of Minnesota, corresponding author) |
| Editors | Abdullah Yusuf (0000-0002-8551-7185) |
| Year | 2022 |
| Volume | 2 |
| Issue | 5 |
| Pages | e0000254 |
| Publication date | 2022-05-16 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | PLOS Global Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2767-3375 • E-ISSN: 2767-3375 |
| Publisher | Public Library of Science (PLoS) (PUBLISHER) |
| DOI | 10.1371/journal.pgph.0000254 |
| PMID | 36713975 |
| OpenAlex | W4280569146 |
| Language | EN |
| Citations received | 1 |
| References cited | 20 |
In rural areas of sub-Saharan Africa, infrastructure and resources for treatment of cryptococcal meningitis (CM) are often lacking. We introduced a CM diagnosis and treatment program (CM-DTP) at Lira Regional Referral Hospital (LRRH) in rural Uganda to determine if implementing high-quality standard of care protocols would improve outcomes. Information extracted from hospital charts and clinical record forms at LRRH were used to compare diagnoses, treatments, and outcomes for all patients diagnosed with meningitis (n = 281) over a two-year period after initiation of the CM-DTP in February of 2017 to all patients diagnosed with meningitis (n = 215) in the two preceding years. After implementation of the CM-DTP, we observed increased confirmed diagnoses of CM from 22.2% (48 of 215) to 35.2% (99 of 281), (p = 0.002) among all patients diagnosed with meningitis. Among all patients treated for CM, the proportion who received standard of care treatment with amphotericin B plus fluconazole increased from 63 of 127 (49.6%) to 109 of 146 (74.7%), (p
Business · Cryptococcal meningitis · Family medicine · Lira · Meningitis · Referral · Rural area · Viral disease · Antifungal resistance and susceptibility · Fungal Infections and Studies · Medicine · Nail Diseases and Treatments · Finance · Pediatrics
| Citations per year | 1 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |