Digit ratio (2D:4D) in Chinese women with breast cancer
Dados Bibliográficos
| AUTOR(ES) | |
|---|---|
| AFILIAÇÃO(ÕES) | Department of Medical Genetic and Cell Biology Ningxia Medical University Yinchuan 750004 China, Medical Reproductive Center, General Hospital, Ningxia Medical University Yinchuan 750004 China |
| ANO | Não informado |
| TIPO | Artigo |
| DOI | 10.1002/ajhb.22546 |
| CITAÇÕES | 4 |
| ADICIONADO EM | 2025-08-18 |
Resumo
ObjectivesDigit ratio, especially second‐to‐fourth digit ratio (2D:4D) is established in utero and is positively correlated with oestrogen in men and women. It is a putative biomarker for prenatal hormone exposure and may represent an individual predisposition to certain diseases (e.g., breast cancer). The aim of the present study is to investigate whether there is a link between digit ratio (2D:4D) and breast cancer in Chinese populations.MethodsThe controls we chose were healthy subjects‐age and ‐sex matched to the patients diagnosed with breast cancer. Photocopies of the two hands of 218 women (controls: 109; patients: 109) were collected. Left hand, right hand, mean hand, and right minus left 2D:4D (Dr−l) were analyzed.ResultsThe patients with breast cancer presented significantly higher 2D:4D than controls (left: P < 0.01; right: P < 0.05; mean: P < 0.05). The mean values of 2D:4D on the left hand were significantly higher than those on the right hand in the two groups, respectively (controls: P < 0.05; patients: P ≤ 0.01). In patients, there was a significantly negative correlation between 2D:4D (left hand: P < 0.01; right hand, mean: P < 0.05) and the presented age with breast cancer, but no association between Dr−l and age of presented disease.ConclusionsDigit ratio (2D:4D) may correlate with the increased risk of breast cancer. Am. J. Hum. Biol. 26:562–564, 2014. © 2014 Wiley Periodicals, Inc.