Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight/obesity
Dados Bibliográficos
| AUTOR(ES) | |
|---|---|
| AFILIAÇÃO(ÕES) | Max Planck Institute for Human Development, Berlin, Germany, and University of Granada, Spain,, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn) Instituto de Salud Carlos III Madrid Spain, Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine University of California at Irvine Irvine California USA |
| ANO | Não informado |
| TIPO | Article |
| ADICIONADO EM | 2025-08-18 |
Resumo
BackgroundChildren with overweight/obesity often exhibit alterations in their plasma protein profiles and reduced heart rate variability (HRV). Plasma proteomics is at the forefront of identifying biomarkers for various clinical conditions. We aimed to examine the association between plasma‐targeted proteomics involved in cardiovascular health and resting vagal‐related HRV parameters in children with overweight/obesity.MethodsForty‐four children with overweight/obesity (10.2 ± 1.1 years old; 52% boys) participated in the study. Olink's technology was used to quantify 92 proteins involved in cardiovascular health. HRV was measured using a heart rate monitor (Polar RS800CX). Four resting vagal‐related HRV parameters were derived in time‐ and frequency‐domain.ResultsEight proteins (KIM1, IgG Fc receptor II‐b, IDUA, BOC, IL1RL2, TNFRSF11A, VSIG2, and TF) were associated with at least one out of the four vagal‐related HRV parameters (β values ranging from −0.188 to 0.288; all p 0.05]).ConclusionPlasma‐targeted proteomics suggested novel biomarkers for resting vagal‐related HRV parameters in children with overweight/obesity. Future studies using larger cohorts and longitudinal designs should confirm our findings and their potential clinical implications.