Soil‐Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species‐Specific Effects Within the Old Friends Hypothesis
Dados Bibliográficos
| AUTOR(ES) | |
|---|---|
| AFILIAÇÃO(ÕES) | University of Oregon, Department of Chronic Disease Epidemiology Yale University School of Public Health New Haven Connecticut USA, Baylor University, Department of Anthropology Washington University in St. Louis St. Louis Missouri USA, Department of Anthropology Northern Arizona University Flagstaff Arizona USA, Department of Anthropology University of Colorado Colorado Springs Colorado Springs Colorado USA, The City University of New York |
| ANO | Não informado |
| TIPO | Artigo |
| DOI | 10.1002/ajhb.70076 |
| CITAÇÕES | 1 |
| ADICIONADO EM | 2025-08-18 |
Resumo
ObjectivesThe old friends hypothesis (OFH) examines connections between the global increase in immunoregulatory diseases (e.g., allergy and autoimmunity) and reduced exposure to immune‐priming symbionts like soil‐transmitted helminths. Helminth species, however, vary in their effects on hosts and should be considered separately. We examined relationships between species‐specific helminth infection and circulating biomarkers of adaptive immune antibodies (total immunoglobulin E [IgE]), systemic inflammation (C‐reactive protein [CRP]), and immune regulation (interleukin‐6 [IL‐6]), among Indigenous Shuar adults. We predicted that STH infection would be (1) associated with higher levels of IgE and (2) lower levels of CRP, with (3) IL‐6 driving these associations based on species‐specific relationships.MethodsOne hundred and seventeen Shuar adults provided stool and finger‐prick blood samples. BCa bootstrap ANCOVA and partial correlation tests examined relationships among infection status (uninfected, Ascaris infected, Trichuris infected, coinfected), control variables (region, sex, age, body mass), and immune biomarkers.ResultsOn average, coinfected participants had the highest IgE compared to all other groups. Ascaris‐infected individuals had, on average, the lowest CRP levels compared to any other group; this was only significant compared to uninfected participants (p < 0.05). Notably, IL‐6 was positively correlated with IgE in Ascaris‐infected individuals (p < 0.05) and with CRP in Trichuris‐infected individuals (p < 0.05), highlighting its role in differentiating between immunoregulation and inflammation based on species‐specific infections.ConclusionsImmune biomarkers varied by infection status: Ascaris infection may downregulate and Trichuris infection may exacerbate systemic inflammation. These preliminary findings suggest that STH species must be considered separately within the OFH.