Assessing effects of Equisetum ramosissimum extract on hematological and serum biochemical parameters in pregnant Sprague-Dawley rats
Bibliographic Data
| ID | 20345533 |
|---|---|
| Authors | Hana Dawood Alebous (0000-0002-5909-9549, corresponding author), Arwa Ali Hudeb, Suzanne Ali Sober, Rosianna Gray (University of Alabama), Margaret Dean Johnson (0000-0003-2681-2528) |
| Year | 2016 |
| Volume | 13 |
| Issue | 3 |
| Pages | 16 |
| Publication date | 2016-03-16 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v13i3.2 |
| OpenAlex | W4255877509 |
| Language | EN |
| References cited | 2 |
Background: As a medicinal herb, Equisetum ramossisemum has been utilized for centuries as a diuretic and has been recommended for different disorders. The aim of this study was to investigate the maternal toxicity of aerial parts of Equisetum ramosissimum extract on pregnant Sprague-Dawley rats.Methods: Females were mated and the coupling time was recorded at gestation day 0– E0. Four experimental groups I, II, III, and IV, received daily gavage doses of 0 mg, 500 mg, 250 mg, and 125 mg/kg, respectively, of Equisetum ramosissimum extract. Pregnant rats were observed for mortality and toxicological effects during daily treatment. On day E20, samples of blood were withdrawn from the retro-orbital sinus under light ether anaesthesia for haematological and clinical chemistry examinations.Results: Data analyses detected significant differences in biochemical and haematological parameters between the control group and other groups receiving extract.Conclusion: This study constitutes a first approach to defining adverse effects of using Equisetum ramosissimum as a medicinal plant during pregnancy. Daily gavage doses of Equisetum ramosissimum extract produced significant differences in biochemical and haematological parameters in pregnant Sprague-Dawley rats as compared to the control group.Keywords: Equisetum ramosissimum extract; Pregnant Sprague -Dawley rats; Haematology; Serum
Animal science · Biology · Diuretic · Gestation · Pregnancy · Toxicity · Complementary and Alternative Medicine Studies · Drug-Induced Hepatotoxicity and Protection · Medicine · Phytochemical and Pharmacological Studies · Internal Medicine · Pharmacology · Physiology
| Highly cited | No |
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