Potential Administration of Lipoic Acid and Coenzyme Q Against Adipogensis
Target for Weight Reduction
Bibliographic Data
| ID | 20345712 |
|---|---|
| Authors | Maryam A Aghamdi (King Abdulaziz University), Hani Choudhry (0000-0003-0401-6619, King Abdulaziz University), Huda A AL-Doghather, Etimad H huwait, Etimad Huwait (0000-0002-4657-6668), Taha A Kumosani (Ain Shams University), Said S Moselhy (0000-0002-2384-3700, Ain Shams University, corresponding author) |
| Year | 2016 |
| Volume | 14 |
| Issue | 1 |
| Pages | 272-277 |
| Publication date | 2016-12-23 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER) |
| DOI | 10.21010/ajtcam.v14i1.29 |
| PMID | 28480405 |
| OpenAlex | W2554080127 |
| Language | EN |
| References cited | 1 |
BACKGROUND: Body overweight and obesity were considered as a risk factor for many systemic diseases as diabetic hypertension, cardiovascular diseases, and some cancers. The lipoic acid and Co Q are considered as coenzymes needed for enhancement metabolic rate. The goal of this study is to evaluate the anti-obese effect of lipoic acid alone or combined with Co-Q in rats. MATERIALS AND METHODS: Ninety male albino rats (100-150g) were used in this study, divided into six groups (15 each). Group I: Normal rats fed normal diet. Group II: Rats fed high fat diet (HFD). Group III: Rats fed HFD were given lipoic acid (10 μg/kg b w/day) intra-gastric by stomach tube. Group IV: Rats fed HFD were given Co-Q (10 μg/kg b.w/day) intra-gastric. Group V: Rats fed HFD were given lipoic acid (50 mg/kg b w/day) and Co-Q (10 μg/kg b. w/day). Group VI: Rats were given orlistat intra-gastric (10 mg/kg b w/day) as positive control for 6 weeks. Serum was subjected for determination of lipid profile, liver function tests atherogenic factor and lipoprotein lipase. RESULTS: <0.001). The effect of combined gives good results than orlistat or individual treatment. CONCLUSION: lipoic acid combined with Co-Q increase fat oxidation and prevent fat accumulation. The consumption of lipoic acid daily promotes fat oxidation and prevents its accumulation in visceral tissues. Further studies should be carried out to examine the mechanistic signals of these nutrients that helps in weight management
Coenzyme A · Enzyme · Lipoic acid · Obesity · Orlistat · Reductase · Weight loss · Biochemical Acid Research Studies · Chemistry · Medicine · Natural Antidiabetic Agents Studies · Peroxisome Proliferator-Activated Receptors · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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