The investigations of total antioxidant status and biochemical serum profile in thymoquinone-treated rats
Bibliographic Data
| ID | 20345833 |
|---|---|
| Authors | E Kurt (Van Yüzüncü Yıl Üniversitesi, corresponding author), Semiha Dede (0000-0001-5744-6327, Van Yüzüncü Yıl Üniversitesi, corresponding author), C Ragbetli, Cennet Rağbetlı (0000-0001-5876-5215) |
| Year | 2015 |
| Volume | 12 |
| Issue | 2 |
| Pages | 68 |
| Publication date | 2015-04-13 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v12i2.13 |
| OpenAlex | W4253651878 |
| Language | EN |
| Citations received | 1 |
| References cited | 3 |
Background: This study was planned to determine the dosage and duration of thymoquinone (TQ) at which it demonstrates the optimum effect on the total antioxidant status (TAS) and the biochemical parameters in the blood serum.Materials and Methods: 48 male rats (Wistar-albino) weighing between 200-250 g were used as material. Group 1 (control) (TQ solution 5 mg/kg/day), Group 2 (15 mg/kg/day), Group 3 (30 mg/kg/day), Group 4 (45 mg/kg/day) and Group 5 (60 mg/kg/day) were designated, each containing 8 rats. Different doses of TQ (oral gavage) were administered for four weeks.Results: The TAS levels were determined to be considerably low statistically in all TQ-administered groups in comparison with the control group. It was determined that the serum biochemical parameters exerted a significant effect depending on the TQ doses.Conclusion: As a result, rats administered with TQ orally, at 60 mg/kg dosage, show that the liver and kidney function parameters in particular as different from normal. This brings us to the conclusion that at this dosage, there is reliable biochemical wise but future protective studies in which 30 mg/kg doses can be used safely is encouraged.Key words: biochemical parameters, rat, thymoquinone, total antioxidant status (TAS)
Antioxidant · Antioxidant capacity · Thymoquinone · Chemistry · Medicine · Nigella sativa pharmacological applications · Biochemistry · Pharmacology
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| Unique citing works | 1 |
|---|---|
| Citations per year | 0,1 |
| Citation span | 2016 - 2016 (1) |
| Citation velocity | historical |
| Highly cited | No |