Anti hyperglycemic activities of Annona muricata (Linn)
Bibliographic Data
| ID | 20345839 |
|---|---|
| Authors | K Aderibigbe, Komolafe Omobola Aderibigbe (0000-0001-9077-6467, Obafemi Awolowo University), OA Komolafe (Obafemi Awolowo University), OS Adewole (Obafemi Awolowo University), Efere M Obuotor (0000-0001-7302-3957, Obafemi Awolowo University), EM Obuotor, TK Adenowo (Olabisi Onabanjo University) |
| Year | 2010 |
| Volume | 6 |
| Issue | 1 |
| Pages | 62-9 |
| Publication date | 2010-07-27 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v6i1.57075 |
| PMID | 20162043 |
| OpenAlex | W2060554060 |
| Language | EN |
| Citations received | 3 |
| References cited | 8 |
This study was designed to determine the effects of methanolic extracts of Annona muricata (Linn) on the blood glucose level of streptozotocin-induced diabetic Wistar rats. Thirty adult Wistar rats were randomly assigned into three groups (A, B and C) of ten rats each. Group A was the control, Group B was untreated hyperglycemic group and group C was A. muricata-treated group. Hyperglycemia was induced in groups B and C by a single intraperitoneal injection of 80 mg/kg streptozotocin dissolved in 0.1 M citrate buffer. The control group was intraperitoneally injected with equivalent volume of citrate buffer and all the animals were monitored for four weeks. Daily intra peritoneal injection of 100 mg/kg A. muricata was administered to group C rats for two weeks and the animals were monitored for another two weeks. The data obtained were analyzed with descriptive and inferential statistics. The result showed a mean body weight of 206 +/- 7.74 g, 173.29+/-5.13 g and 197 +/- 5.62 g respectively for the control, untreated diabetic and A. muricata-treated diabetic group, and a mean blood glucose concentration of 3.78 +/- 0.190 mmol/L, 21.64 +/- 2.229 mmol/L and 4.22 +/- 0.151 mmol/L for the control, untreated diabetic and treated diabetic groups respectively. A significant difference exists between the blood glucose concentrations of treated and untreated hyperglycemic groups of rats. The result of this study demonstrated that A. muricata possesses anti-hyperglycemic activities
Annona muricata · Body weight · Diabetes mellitus · Group B · Intraperitoneal injection · Negative control · Streptozotocin · Traditional medicine · Medicine · Natural Antidiabetic Agents Studies · Psidium guajava Extracts and Applications · Traditional and Medicinal Uses of Annonaceae · Endocrinology · Internal Medicine
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| Unique citing works | 3 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2014 - 2018 (5) |
| Citation velocity | historical |
| Highly cited | No |