Antioxidant activity of Piper caninum and Cyclooxygenase-2 inhibition by methoxylated flavones
Bibliographic Data
| ID | 20345925 |
|---|---|
| Authors | MH Nadri (University of Technology Malaysia), MA Naser (University of Technology Malaysia), RM Zukifli (University of Technology Malaysia), II Muhamad (University of Technology Malaysia), Faridahanim Ahmad (0000-0002-9923-7934, University of Technology Malaysia), WMNHW Salleh (University of Technology Malaysia), HM Sirat (University of Technology Malaysia) |
| Year | 2015 |
| Volume | 12 |
| Issue | 2 |
| Pages | 120 |
| Publication date | 2015-04-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v12i2.18 |
| OpenAlex | W2009106763 |
| Language | EN |
| References cited | 2 |
Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones.Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively.Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations.Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrationsKey words: Piper caninum; antioxidant; cyclooxygenase-2.List of abbreviations: COX-2, cyclooxygenase-2; DPPH, 2,2-diphenyl- 1-picrylhydrazyl; PGE2, prostaglandin E2
Antioxidant · Chromatography · Cyclooxygenase · DPPH · Enzyme · Flavones · Piper · Traditional medicine · Chemistry · Free Radicals and Antioxidants · Medicine · Phytochemicals and Antioxidant Activities · Piperaceae Chemical and Biological Studies · Biochemistry · Food Science
| Highly cited | No |
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