Antioxidant Properties of Dichrocephala Integrifolia (Asteraceae) in a Mouse Model of Monosodium Glutamate-Induced Neurotoxicity
Bibliographic Data
| ID | 20346115 |
|---|---|
| Authors | Kouémou Emégam Nadège (University of Ngaoundere, corresponding author), Dongmo Nguepi Mireille Sylviane (University of Buea), Fotio Lambou Agathe, Fotio Lambou Tonfack Agathe (University of Buea), Moto Okomolo Fleur Clarisse (Université de Yaoundé I), Taiwe Sotoing Germain, Pahaye Bougolla David (University of Ngaoundere), Simon Pale (0009-0008-6084-4674, University of Ngaoundere), Pale Simon, Njapdounke Kameni Jacqueline Stephanie (University of Ngaoundere), Ngo Bum Elisabeth (University of Maroua) |
| Year | 2017 |
| Volume | 14 |
| Issue | 5 |
| Pages | 147-155 |
| Publication date | 2017-10-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER) |
| DOI | 10.21010/ajtcam.v14i5.18 |
| OpenAlex | W2761646449 |
| Language | EN |
| Citations received | 1 |
| References cited | 2 |
Background: In Africa, neurodegenerative diseases in the elderly have become a major health concern due to the increase in live expectancy. Glutamate mediated neurotoxicity is involved in neurodegenerative diseases such as Ischemia, Epilepsy, Alzheimer’s and Parkinson diseases. Plants with antioxidant properties are reported to protect vital organs against glutamate toxicity. This study aims to assess the effect of Dichrocephala integrifolia against monosodium glutamatemediated neurotoxicity and oxidative stress. Methodology: The decoction prepared from the leaves of Dichrocephala integrifolia was evaluated against monosodium glutamate-induced neurotoxicity in mice. The animals were grouped in seven groups of 6 animals each. The animals received daily; distilled water (p.o) for the distilled water and the negative control groups, one of the four doses of the decoction of the plant (35, 87.5, 175 or 350 mg/kg p.o) for the tests groups and memantine (20 mg/kg p.o) for the positive control group. Monosodium glutamate (2.5 g/kg ip) was injected daily to animals except those of the normal control group all the seven days of the experimentation. Animals were observed for aggressiveness, locomotor and forepaws muscle grip activities 30 min after monosodium injections. Brain reduced glutathione and malondialdehyde levels were also assessed following the behavioral tests on day 8. Results: The decoction of Dichrocephala integrifolia at the doses of 87.5 and 175 mg/kg significantly (p
Antioxidant · Decoction · Glutamate receptor · Glutathione · Malondialdehyde · Monosodium glutamate · Neurotoxicity · Oxidative stress · Toxicity · Traditional medicine · Biochemical Analysis and Sensing Techniques · Chemistry · Medicinal Plants and Neuroprotection · Medicine · Neuroscience and Neuropharmacology Research · Biochemistry · Internal Medicine · Pharmacology
| Citations per year | 0.25 |
|---|---|
| Citation span | 2022 - 2022 (1) |
| Highly cited | No |