Protective Effects of Moutan Cortex Radicis against Acute Hepatotoxicity
Bibliographic Data
| ID | 20346145 |
|---|---|
| Authors | J Park (0000-0002-7755-4242, Sungkyunkwan University), Hee Young Kim (0000-0002-2243-3240, Sungkyunkwan University), H-Y Kim (Sungkyunkwan University), S-M Lee, SM Lee (Sungkyunkwan University) |
| Year | 2011 |
| Volume | 8 |
| Issue | 5S |
| Pages | 220-5 |
| Publication date | 2011-07-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v8i5s.2 |
| PMID | 22754078 |
| OpenAlex | W2086877297 |
| Language | EN |
| Citations received | 2 |
| References cited | 3 |
This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl(4))-, D-galactosamine (GalN)- and α-naphthylisothiocyanate (ANIT)-induced liver injury. Acute hepatotoxicity was induced by intraperitoneal injection of CCl(4) (10 μL/kg), GalN (700 mg/kg), and ANIT (40 mg/kg). Animals received MCR (30, 100, and 300 mg/kg ) orally at 48, 24, and 2 h before and 6 h after administration of CCl(4), GalN, and ANIT. Serum activities of aminotransferase were significantly higher at 24 h after CCl(4) or GalN treatment. These changes were attenuated by MCR. Histopathological analysis revealed multiple and extensive areas of portal inflammation, hepatocellular necrosis, and an increase in inflammatory cell infiltration. These changes were inhibited by MCR. Serum total bilirubin concentration increased and bile flow decreased significantly 48 h after ANIT treatment, which was attenuated by MCR. Our results suggest that MCR has a protective effect on acute liver injury
Carbon tetrachloride · CCL4 · Inflammation · Intraperitoneal injection · Liver injury · Chemistry · Drug-Induced Hepatotoxicity and Protection · Flavonoids in Medical Research · Healthcare and Venom Research · Medicine · Pharmacological Effects of Natural Compounds · Phytochemistry and Biological Activities · Traditional Chinese Medicine Analysis · Internal Medicine · Pharmacology
| Citations per year | 0.15 |
|---|---|
| Citation span | 2013 - 2023 (11) |
| Highly cited | No |