Acute And Subchronic Toxicity Of Anacardium occidentale Linn (Anacardiaceae) Leaves Hexane Extract In Mice
Bibliographic Data
| ID | 20346240 |
|---|---|
| Authors | Leonard Tedong (Université de Yaoundé I), PDD Dzeufiet (Université de Yaoundé I), Théophile Dimo (0000-0002-8565-1181, Université de Yaoundé I), EA Asongalem (Université de Yaoundé I), SD Sokeng, S N Sokeng (University of Ngaoundere), J-F Flejou, J‐F Flejou (Sorbonne Université), P Callard (Sorbonne Université), Pierre Kamtchouing (0000-0001-7544-427X, Sorbonne Université) |
| Year | 2008 |
| Volume | 4 |
| Issue | 2 |
| Pages | 140-7 |
| Publication date | 2008-09-22 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v4i2.31194 |
| PMID | 20162085 |
| OpenAlex | W2117913819 |
| Language | EN |
| Citations received | 3 |
| References cited | 5 |
These studies focus on the toxicity leaf hexane extract of A. occidentale L (Anacardiaceae) used in Cameroon traditional medicine for the treatment of diabetes and hypertension. Previous findings on antidiabetic and anti-inflammatory have given support to the ethnopharmacological applications of the plant. After acute oral administration, it was found that doses of the extract less than 6 g/kg are not toxic. Signs of toxicity at high doses were asthenia, anorexia, diarrhoea, and syncope. The LD(50) of the extract, determined in mice of both sexes after oral administration was 16 g/kg. In the subchronic study, mice received A. occidentale at doses of 6, 10 and 14 g/kg (by oral route) for 56 days. At doses of 2, 6 and 10 g/kg of extract, repeated oral administration to mice produced a reduction in food intake, weight gain, and behavioural effects. Liver or the kidney function tests were assessed by determining serum parameters like, creatinine, transaminases, and urea. All these parameters were significantly (p<0.01) abnormal. Histopathological studies revealed evidence of microscopic lesions either in the liver or in the kidney which may be correlated with biochemical disturbances. We conclude that toxic effects of A. occidentale L hexane leaf extract occurred at higher doses than those used in Cameroon folk medicine
Acute toxicity · Anacardiaceae · Anacardium · Biology · Botany · Creatinine · Diabetes mellitus · Kidney · Oral administration · Toxicity · Traditional medicine · Urea · Ethnobotanical and Medicinal Plants Studies · Ginkgo biloba and Cashew Applications · Medicine · Natural Antidiabetic Agents Studies · Biochemistry · Endocrinology · Internal Medicine · Pharmacology
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| Citations per year | 0.2 |
|---|---|
| Citation span | 2011 - 2022 (12) |
| Highly cited | No |