Hypolipidemic activities of Ficus racemosa linn. Bark in alloxan induced diabetic rats
Bibliographic Data
| ID | 20346271 |
|---|---|
| Authors | D Sophia (Annamalai University), Shanmugam Manoharan (0000-0001-5233-9071) |
| Year | 2008 |
| Volume | 4 |
| Issue | 3 |
| Pages | 279 |
| Publication date | 2008-10-14 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v4i3.31220 |
| PMID | 20161890 |
| OpenAlex | W1950643055 |
| Language | EN |
| Citations received | 5 |
| References cited | 1 |
Ficus racemosa (Moraceae family) is used in traditional system of medicine for the treatment of several disorders including diabetes mellitus. The aim of the study was to investigate the antihyperglycemic and hypolipidemic activities of ethanolic extract of Ficus racemosa bark (FrEBet) in alloxan-induced diabetic rats. A total number of 30 animals were divided into 5 groups of six each. Diabetes mellitus was induced by single intraperitoneal injection of freshly prepared solution of alloxan monohydrate (150 mg/kg bw) dissolved in physiological saline in overnight fasted wistar rats. Dose dependent studies for FrEBet (100-500 mg/kg bw) was carried out to find out the effective pharmacological dose (antidiabetic and hypolipidemic) to alloxan-induced diabetic rats. Blood glucose, plasma insulin, total cholesterol, phospholipids, triglycerides, free fatty acids, HDL cholesterol and LDL cholesterol levels in plasma, erythrocyte membranes, liver and kidney were determined by specific colorimetric methods. An increase in blood glucose was accompanied by an increase in total cholesterol, phospholipids, triglycerides, FFA and decrease in HDL cholesterol in diabetic rats. Oral administration of FrEBet (300 mg/kg bw) to diabetic rats restored the status of blood glucose, lipids and lipoproteins to near normal range. Our investigation thus shows that FrEBet has potent antidiabetic and hypolipidemic effects in alloxan-induced diabetic rats and these effects were much comparable to that of the standard reference drug, glibenclamide
Alloxan · Cholesterol · Diabetes mellitus · Glibenclamide · Moraceae · Traditional medicine · Chemistry · Diabetes, Cardiovascular Risks, and Lipoproteins · Medicine · Natural Antidiabetic Agents Studies · Phytochemistry and biological activities of Ficus species · Endocrinology · Internal Medicine · Pharmacology
Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats
The genus Ficus (Moraceae) used in diet
Traditional management of diabetes in Pakistan
A role of Ficus species in the management of diabetes mellitus
Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh - an ethnobotanical survey
| Citations per year | 0.38 |
|---|---|
| Citation span | 2013 - 2018 (6) |
| Highly cited | No |