A study on the inhibitory effect of matrine on gastric cancer SGC-7901 cells

Bibliographic Data

ID20346316
AuthorsS Song (0000-0002-1178-9997), Si Yeol Song (0000-0003-0090-8345, Hubei University of Medicine), Shuyu Zhu (0000-0002-3791-8400, Hubei University of Medicine), Zhengwang Zhang (0000-0003-1063-7198, Hubei University of Medicine), Zhaohui Mo (0000-0002-5181-048X, Hubei University of Medicine), Qiong Ke (0000-0003-2566-7242, Hubei University of Medicine), Zhaohui Luo (0000-0002-2289-5533, Hubei University of Medicine)
Year2013
Volume10
Issue6
Pages435
Publication date2013-10-14
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAfrican Journal of Traditional Complementary and Alternative Medicines (JOURNAL)
Journal identifiersISSN: 0189-6016 • E-ISSN: 2505-0044
PublisherAfrican Journals Online (AJOL) (PUBLISHER)
DOI10.4314/ajtcam.v10i6.5
PMID24311863
OpenAlexW2033132459
LanguageEN
Citations received1

The objective of this paper was to investigate the antitumour mechanism of action of matrine by studying its inhibitory effect on gastric cancer SGC-7901 cells. SGC-7901 cells were chosen, and cell-killing capacity of matrine on gastric cancer SGC-7901 cells was determined using MTT assay and single PI staining assay. The results showed that matrine had an inhibitory effect on gastric cancer SGC-7901 cells, which was somewhat dose-dependent. The study concluded that matrine has a significant in-vitro inhibitory effect on SGC-7901 tumour cells, influences cell cycle of SGC-7901 cells, and induces their apoptosis

Apoptosis · Biology · Cancer · Cancer cell · Cell · Cell cycle · In vitro · Inhibitory postsynaptic potential · Matrine · MTT assay · Pathology · Staining · Bioactive Compounds and Antitumor Agents · Cell death mechanisms and regulation · Chemistry · Medicine · RNA Interference and Gene Delivery · Biochemistry · Cancer Research · Internal Medicine · Molecular Biology · Pharmacology

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