Effect of administration of aqueous extract of Hippobromus pauciflorus leaves in male wistar rats

Bibliographic Data

ID20346343
AuthorsS C Pendota (University of Fort Hare), Musa Toyin Yakubu (0000-0002-3310-5795, University of Fort Hare), D S Grierson, Donald Grierson (0000-0002-2238-8072, University of Fort Hare), Anthony Jide Afolayan (0000-0002-9111-6695, University of Fort Hare)
Year2010
Volume7
Issue1
Pages40-6
Publication date2010-07-30
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAfrican Journal of Traditional Complementary and Alternative Medicines (JOURNAL)
Journal identifiersISSN: 0189-6016 • E-ISSN: 2505-0044
PublisherAfrican Journals Online (AJOL) (PUBLISHER)
DOI10.4314/ajtcam.v7i1.57237
PMID21304611
OpenAlexW1973064500
LanguageEN
Citations received1
References cited4

The effect of administration of aqueous extract of Hippobromus pauciflorus (L.f.) Radlk (Sapindaceae) leaves at 50, 100 and 200 mg/kg body weight for 14 days on some biochemical parameters in male Wistar rats was investigated. The extract at all the doses tested did not significantly (P>0.05) alter the levels of white blood cells, red blood cells, mean corpuscular volume, platelets, neutrophils, monocytes, lymphocytes and large unstained cells. While the levels of haemoglobin, packed cell volume and basophils increased significantly (P 0.05) altered. However, the extract significantly (P<0.05) increased the concentration of triacylglycerol. The results suggest that the extract has mild and dose specific haemato-, hepato- and nephrotoxic effects and may not be completely safe as oral remedy at the doses investigated

Aqueous extract · Biology · Body weight · Botany · Hematocrit · Mean corpuscular volume · Platelet · Sapindaceae · Traditional medicine · White blood cell · Chemistry · Drug-Induced Hepatotoxicity and Protection · Ethnobotanical and Medicinal Plants Studies · Medicine · Natural Antidiabetic Agents Studies · Endocrinology · Internal Medicine

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