Geno Protective and Anti-Apoptotic Effect of Green Tea Against Perinatal Lipopolysaccharide-Exposure Induced Liver Toxicity in Rat Newborns
Bibliographic Data
| ID | 20346409 |
|---|---|
| Authors | Ahmed A Allam (0000-0003-0702-8025, Beni-Suef University, corresponding author), Sami A Gabr (0000-0001-5071-291X), Sami Gabr (0000-0003-4965-5852, Mansoura University), Jamaan Ajarem, Jamaan S Ajarem (0000-0003-2151-445X, King Saud University), Ahmad H Alghadir (0000-0002-1204-476X, King Saud Medical City), Revathi Sekar (0000-0002-6787-7742, University of Hong Kong), Billy KC Chow, Bkc Chow (0000-0003-3390-0307, University of Hong Kong) |
| Year | 2017 |
| Volume | 14 |
| Issue | 2 |
| Pages | 166-176 |
| Publication date | 2017-01-13 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER) |
| DOI | 10.21010/ajtcam.v14i2.18 |
| PMID | 28573233 |
| OpenAlex | W2588908953 |
| Language | EN |
| References cited | 2 |
Background: This study aims to examine the protective effect of green tea on the disturbances in oxidative stress and apoptosis related factors, mostly produced due to perinatal lipopolysaccharide (LPS) exposure, that subsequently induces liver cell damage. Materials and Methods: Anti-free radical, Antioxidant, scavenging, geno-protective, and antiapoptotic activity of aqueous green tea extract (AGTE) were assessed against LPS-induced hepatic dysfunction in newborn-rats. AGTE at doses of 100 & 200 mg/kg was orally administered daily to rat dams, during gestation and lactation. Results: AGTE was observed to exhibit protective effects by significantly attenuating LPS-induced alterations in serum AST, ALT, bilirubin, and albumin levels. Significant increase in the total antioxidant capacity (TAC), DNA contents, and reduction in nitric oxide (NO) levels were observed in AGTE treated rats comparing LPS-toxicated ones. Additionally, AGTE treatment significantly down-regulated apoptotic markers and this effect was directly correlated to the degree of hepatic fibrosis. The possible mechanisms of the potential therapeutic-liver protective effect of AGTE could be due to free radical scavenging potential and antiapoptotic properties caused by the presence of antioxidant polyphenolic components in AGTE. Conclusion: We thereby propose, based on our findings, that the anti-free radical and anti-apoptotic inducing properties of AGTE active constituents attribute to its functional efficacy as anti-fibrotic agent
Antioxidant · Apoptosis · Hepatic stellate cell · Lipopolysaccharide · Nitric oxide · Oxidative stress · Polyphenol · Toxicity · Chemistry · Heavy Metals in Plants · Medicine · Tea Polyphenols and Effects · Traditional Chinese Medicine Analysis · Biochemistry · Endocrinology · Immunology · Internal Medicine · Pharmacology
| Highly cited | No |
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