The preventive effect and enhance immunity function of Bu-zhong-yi-qi wan on s180 tumor mice
Dados Bibliográficos
| ID | 20346552 |
|---|---|
| Autores | Fang Hu (0000-0002-3725-2936, The First People's Hospital of Tianmen), Xiaoya Liu (0000-0002-4361-5166, Lanzhou University), Xiao-ya Liu, Xinyue Chen (0000-0003-2181-5172, Lanzhou University), Xin-Yue Chen, Can Li (0000-0001-8438-1549), Rui-juan Zhu, Ruijuan Zhu (Lanzhou University), Huan Huan (0009-0000-5685-1697, Lanzhou University), Yingdong Li (0000-0001-7184-7290, Gansu University of Traditional Chinese Medicine), Ying-dong Li, Shilan Feng (Lanzhou University), Shi-lan Feng |
| Ano | 2016 |
| Volume | 13 |
| Fascículo | 3 |
| Páginas | 60 |
| Data de publicação | 2016-03-16 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Identificadores do periódico | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Editora | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v13i3.8 |
| OpenAlex | W2297451669 |
| Idioma | EN |
| Referências citadas | 2 |
Background: To evaluate the preventive effect and enhance immunity functions of Bu-zhong-yi-qi wan in vivo.Materials and Methods: S180 tumor mice model was established by subcutaneous injection a dose of 0.2 ml (1×107/ml) at the right oxter. The inhibitory rates, spleen indexes and thymus indexes were calculated. Splenic lymphocyte proliferative activity assay and phagocytosis activity of peritoneal macrophages were done. Interferon (IFN-γ), interleukin (IL-2) and tumor necrotic factor (TNF-α) in serum were detected.Results: In the S180 tumor-bearing mice, Bu-zhong-yi-qi wan with medium-dose (975 mg/kg, 100 mg/l) had potent preventive effect and anti-tumor effect, macrophage phagocytosis and Con A-stimulated splenocyte proliferation were increased as compared with model control treatment. Bu-zhong-yi-qi wan could take part in the immune response by promoting the proliferation and differentiation of Tcells, increasing the activity of the macrophages, inducing the generation of cell factor IL-2, TNF-α, IFN-γ.Conclusion: It proved that Bu-zhong-yi-qi wan of medium-dose had great preventive effect and could enhance immunity function.Keywords: Bu-zhong-yi-qi wan, S180 tumor-bearing mice, preventive, immunity
Biology · Immune system · Immunity · In vitro · In vivo · Macrophage · Phagocytosis · Spleen · Splenocyte · Subcutaneous injection · Traditional medicine · Tumor necrosis factor alpha · Chemistry · Healthcare and Venom Research · Medicine · Microbial Metabolism and Applications · Pharmacological Effects of Natural Compounds · Biochemistry · Biotechnology · Immunology · Internal Medicine · Pharmacology
| Velocidade de citação | historical |
|---|---|
| Altamente citado | Não |