Hepatic, Renal and Endogenous Antioxidant Status Modulatory Effects of Chronic Co-Supplementation of Rooibos (Aspalathus Linearis) and Red Palm Oil (Elaeis Guineensis) in Male Wistar Rats
Bibliographic Data
| ID | 20346731 |
|---|---|
| Authors | Olawale Razaq Ajuwon (0000-0003-3958-1685, Cape Peninsula University of Technology), Oluwafemi Omoniyi Oguntibeju (0000-0002-7299-1128, Cape Peninsula University of Technology), Jeanine L Marnewick (0000-0002-1819-1699, Cape Peninsula University of Technology, corresponding author) |
| Year | 2016 |
| Volume | 13 |
| Issue | 3 |
| Pages | 1-15 |
| Publication date | 2016-03-15 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER) |
| DOI | 10.21010/ajtcam.v13i3.1 |
| OpenAlex | W4299967972 |
| Language | EN |
| References cited | 5 |
Background: This study investigated the hepatic, renal and endogenous antioxidant status modulatory effects of chronic cosupplementation of rooibos and red palm oil (RPO) in male Wistar rats. Materials and Methods: Rats were randomized into four groups (n=10/group) and fed daily either standard rat chow (SRC) and water (Group I), SRC and the aqueous rooibos extract (2% w/v; Group II), SRC and RPO (200 μL/day) with water (Group III), or SRC and RPO (200 μL/day) with rooibos (2% w/v; Group IV) for 22 weeks. Results: Chronic feeding of rooibos, RPO or their combination did not induce any adverse hepatic or renal effects, as shown by serum levels of alkaline phosphatase, alanine- and aspartate aminotransferase, lactate dehydrogenase, albumin, creatinine, blood urea nitrogen and uric acid. Histopathology analyses showed that liver from the three supplementation groups displayed normal hepatic histoarchitecture. Chronic feeding of RPO did not influence the redox status in the blood and liver significantly. Supplementation of rooibos alone for 22 weeks significantly (P
Albumin · Alkaline phosphatase · Antioxidant · Bilirubin · Blood urea nitrogen · Creatinine · Enzyme · Garlic Oil · Lactate dehydrogenase · Uric acid · Chemistry · Coconut Research and Applications · Edible Oils Quality and Analysis · Fatty Acid Research and Health · Medicine · Biochemistry · Endocrinology · Food Science · Internal Medicine
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| Highly cited | No |
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