The Preventive Effect and Enhance Immunity Function of Bu-Zhong-Yi-Qiwan on S180 Tumor Mice
Bibliographic Data
| ID | 20346846 |
|---|---|
| Authors | Fang Hu (0000-0002-3725-2936, The First People's Hospital of Tianmen), Xiaoya Liu (0000-0002-4361-5166, Lanzhou University), Xinyue Chen (0000-0003-2181-5172, Lanzhou University), Can Li (0000-0001-8438-1549), Ruijuan Zhu (Lanzhou University), Huan Han (0000-0001-8287-3785, Lanzhou University), Yingdong Li (0000-0001-7184-7290, Gansu University of Traditional Chinese Medicine), Shilan Feng (Lanzhou University) |
| Year | 2016 |
| Volume | 13 |
| Issue | 3 |
| Pages | 60-65 |
| Publication date | 2016-03-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER) |
| DOI | 10.21010/ajtcam.v13i3.8 |
| OpenAlex | W4301118552 |
| Language | EN |
| References cited | 2 |
Background: To evaluate the preventive effect and enhance immunity functions of Bu-zhong-yi-qi wan in vivo. Materials and Methods: S180 tumor mice model was established by subcutaneous injection a dose of 0.2 ml (1×107/ml) at the right oxter. The inhibitory rates, spleen indexes and thymus indexes were calculated. Splenic lymphocyte proliferative activity assay and phagocytosis activity of peritoneal macrophages were done. Interferon (IFN-γ), interleukin (IL-2) and tumor necrotic factor (TNF-α) in serum were detected. Results: In the S180 tumor-bearing mice, Bu-zhong-yi-qi wan with medium-dose (975 mg/kg, 100 mg/l) had potent preventive effect and anti-tumor effect, macrophage phagocytosis and Con A-stimulated splenocyte proliferation were increased as compared with model control treatment. Bu-zhong-yi-qi wan could take part in the immune response by promoting the proliferation and differentiation of Tcells, increasing the activity of the macrophages, inducing the generation of cell factor IL-2, TNF-α, IFN-γ. Conclusion: It proved that Bu-zhong-yi-qi wan of medium-dose had great preventive effect and could enhance immunity function
Biology · Immune system · Immunity · In vitro · In vivo · Macrophage · Phagocytosis · Spleen · Splenocyte · Subcutaneous injection · Tumor necrosis factor alpha · Chemistry · Healthcare and Venom Research · Medicine · Biochemistry · Immunology · Internal Medicine · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |