Effects of tephrosia purpurea aqueous seed extract on blood glucose and antioxidant enzyme activities in streptozotocin induced diabetic rats
Bibliographic Data
| ID | 20346868 |
|---|---|
| Authors | P Pavana (Annamalai University), S Sethupathy (0000-0002-6970-1708), K Santha, Shanmugam Manoharan (0000-0001-5233-9071) |
| Year | 2010 |
| Volume | 6 |
| Issue | 1 |
| Pages | 78-86 |
| Publication date | 2010-07-27 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Journal identifiers | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Publisher | African Journals Online (AJOL) (PUBLISHER) |
| DOI | 10.4314/ajtcam.v6i1.57077 |
| PMID | 20162045 |
| OpenAlex | W1986576029 |
| Language | EN |
| References cited | 3 |
The aim of the present study was to evaluate the effects of aqueous seed extract of Tephrosia purpurea (TpASet) on blood glucose and antioxidant status in streptozotocin induced diabetic rats. Hyperglycemia associated with an altered hexokinase and glucose-6-phosphatase activities, elevated lipid peroxidation, disturbed enzymatic [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and non enzymatic [Glutathione, vitamin C and vitamin E] antioxidant status were observed in streptozotocin induced diabetic rats. Oral administration of "TpASet" at a dose of 600 mg/kg body weight showed significant improvement in above mentioned parameters. Our results clearly indicate that "TpASet" has potent antihyperglycemic and antioxidant effects in streptozotocin-induced diabetic rats and therefore further studies are warranted to isolate and characterize the bioactive principles from "TpASet"
Alkaline phosphatase · Antioxidant · Biology · Catalase · Diabetes mellitus · Enzyme · Glutathione · Glutathione peroxidase · Lipid peroxidation · Streptozotocin · Superoxide dismutase · Vitamin C · Vitamin E · Bioactive natural compounds · Chemistry · Diet, Metabolism, and Disease · Medicine · Natural Antidiabetic Agents Studies · Biochemistry · Endocrinology · Internal Medicine · Pharmacology
| Highly cited | No |
|---|