Antiproliferative effect of alcoholic extracts of some Gabonese medicinal plants on human colonic cancer cells

Bibliographic Data

ID20346925
AuthorsM Line-Edwige (Institut Africain d'Informatique), FT Guy Raymond (Université des Sciences et Techniques de Masuku), Éric François (0000-0001-6471-8159), N Edouard, N’guessan Kouakou Edouard (Université des Sciences et Techniques de Masuku)
Year2010
Volume6
Issue2
Pages112-7
Publication date2010-07-28
Open AccessYes
TypeARTICLE
VenueAfrican Journal of Traditional Complementary and Alternative Medicines (JOURNAL)
Journal identifiersISSN: 0189-6016 • E-ISSN: 2505-0044
PublisherAfrican Journals Online (AJOL) (PUBLISHER)
DOI10.4314/ajtcam.v6i2.57081
PMID20209001
OpenAlexW2155790503
LanguageEN
Citations received5
References cited1

Extracts from Piptadeniastrum africanum Brenan (Mimosaceae), Petersianthus macrocarpus (Breauv) L. (Lecydaceae), Cissus debilis Planch (Vitaceae) and Dieffenbachia seguine Jacq. (Araceae) were tested in vitro for their antiproliferative activity on human colon cancer cell line (CaCo-2). The highest antiproliferative activities were obtained with the alcoholic extracts of the roots of Piptadeniastrum africanum (G-PAR), the leaves of Petersianthus macrocarpus (G-PMF) and the stem of Cissus debilis (G-CDL), with 50% inhibition concentrations (IC(50)) of 15 microg/ml, 17 microg/ml and 25 microg/ml respectively. Only one extract (leaves of Dieffenbachia seguine (G-DSF)) exhibited weak antiproliferative activity with 50% inhibition concentration (IC(50)) higher than 50 microg/ml

Cancer · Colonic cancer · Colorectal cancer · Traditional medicine · Chemistry · Ethnobotanical and Medicinal Plants Studies · Medicine · Natural Antidiabetic Agents Studies · Traditional and Medicinal Uses of Annonaceae · Internal Medicine