The association of osteochemometrics and bone mineral density in humans
Dados Bibliográficos
| AUTOR(ES) | |
|---|---|
| AFILIAÇÃO(ÕES) | Centre for Functional Ecology, Laboratory of Forensic Anthropology, Department of Life Sciences, Calçada Martim de Freitas University of Coimbra Coimbra Portugal, Molecular Physical‐Chemistry R&D Unit, Department of Chemistry University of Coimbra Coimbra Portugal, Department of Life Sciences, Calçada Martim de Freitas University of Coimbra Coimbra Portugal |
| ANO | 2021 |
| TIPO | Artigo |
| PERIÓDICO | American Journal of Physical Anthropology |
| ISSN | 0002-9483 |
| E-ISSN | 1096-8644 |
| EDITORA | Berghahn Journals (United Kingdom) |
| DOI | 10.1002/ajpa.24283 |
| ADICIONADO EM | Não informado |
Resumo
ObjectivesEven though much is known about bone mineral and matrix composition, studies about their relationship with several bone properties and its alterations related to bone diseases such as osteoporosis are practically non‐existent in humans. Thus, the development of methods to understand the effects of bone properties at a microscopic level is paramount. This research aimed to evaluate whether Fourier transform infrared‐attenuated total reflectance (FTIR‐ATR) band intensity ratios correlate with femoral bone mass, bone mineral content (BMC) (total and femoral neck), bone mineral per unit area (BMD) (total, femoral neck, greater trochanter, intertrochanteric region, and Ward's area) and the area (total and femoral neck). A sample of femora from the 21st Century Identified Skeleton Collection (N = 78, 42 females and 36 males) was employed and BMC, BMD, and the femoral areas were acquired by DXA.ResultsIt was found that only females' BMD had a significant association with the femoral FTIR‐ATR indices under study, whereas bone collagen (Am/P) and the content of carbonate Type A (API) in males correlated with the total proximal femur area of the regions of interest and the femoral neck area.DiscussionMen and women showed different changes related to their chemical composition in BMD, BMC, and probed area, most likely due to differences in structure and physiology, as well as mechanical strength in the proximal femoral sites where BMD was analyzed.