Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in Central Western Africa
A tentative hypothesis on the interaction between GPX1*2 and Hbβ*S allelic products
Bibliographic Data
| ID | 20538671 |
|---|---|
| Authors | Giovanni Destro‐bisol, Giovanni Destro Bisol (0000-0002-4232-9715, Università Cattolica del Sacro Cuore), Gabriella Spedini (Sapienza University of Rome) |
| Year | 1989 |
| Volume | 79 |
| Issue | 2 |
| Pages | 217-224 |
| Publication date | 1989-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330790209 |
| PMID | 2742004 |
| OpenAlex | W2097171448 |
| Language | EN |
| Citations received | 5 |
| References cited | 28 |
Phenotype and allele frequencies for erythrocyte glutathione peroxidase (GPX1) polymorphism are reported in the Mbugu and Sango (Central African Republic), Goun (Benin), and Bamileke (Cameroon) ethnic groups. The GPX1*2 allele frequencies (from 0.012 in the Sango to 0.058 in the Bamileke) fit into the range of the data already known for the Subsaharan populations. The value of GPX1*2 for study of the genetic admixture between Negro and Pygmy populations is suggested. Three different unusual GPX1 electrotypes are described. Finally, we hypothesize an interaction between GPX1*2 and Hb beta*S allelic products occurring in the sickle cells infected by Plasmodium falciparum
Allele · Biology · Enzyme · Gene · Glutathione · Glutathione peroxidase · GPX1 · Polymorphism (computer science) · Biochemistry · Genetics · Hemoglobinopathies and Related Disorders · Neutrophil, Myeloperoxidase and Oxidative Mechanisms · Trace Elements in Health
A seven year anthropobiological survey on the distribution of abnormal hemoglobins in Cameroon
Variation at 10 protein coding loci in the mbenzele pygmies from the central african republic and a comparison with microsatellite data
Population genetics of Glutathione peroxidase (GPX1) in Central Portugal
The peopling of Sub-Saharan Africa
Interaction between oxidized hemoglobin and the cell membrane
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,17 |
| Citation span | 1996 - 2001 (6) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 5 |