Elevated Plasma C-Reactive Protein in Chronically Distressed Subjects Who Carry the A Allele of the TNF-α −308 G/A Polymorphism
Bibliographic Data
| ID | 20971197 |
|---|---|
| Authors | Pascal Jeanmonod (Ecole polytechnique fédérale de Lausanne), Roland Von Känel (0000-0002-8929-5129), Friedrich E Maly, Jerome E Fischer (0000-0002-7543-1820, corresponding author), Joachim E Fischer |
| Year | 2004 |
| Volume | 66 |
| Issue | 4 |
| Pages | 501-506 |
| Publication date | 2004-07-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/01.psy.0000130903.78444.7d |
| PMID | 15272094 |
| OpenAlex | W2016888770 |
| Language | EN |
| Citations received | 3 |
| References cited | 33 |
OBJECTIVE: Sustained psychological stress may result in a state operationalized as "vital exhaustion." Exhaustion predicted coronary artery disease (CAD) events whereby increased inflammatory activity might mediate this link. Moreover, there is an emerging importance of gene-environmental interactions in CAD. We investigated the effect of exhaustion severity on plasma levels of C-reactive protein (CRP) and whether exhaustion might regulate CRP levels via the -308G/A polymorphism of the tumor necrosis factor (TNF)-alpha gene. METHODS: We assessed exhaustion in 275 industrial employees (mean age +/- SD, 41 +/- 9 years, 88% men) using the Maastricht Questionnaire. Subjects were stratified as per exhaustion severity: none (N = 80), moderate (N = 128), and severe (N = 67). The TNF-alpha polymorphism was determined by real-time polymerase chain reaction, and plasma CRP levels were measured by a high-sensitivity immunoassay. RESULTS: There was a significant interaction between exhaustion and the TNF-alpha polymorphism, explaining 4.5% in the variance of plasma CRP values (F(5,271) = 2.47, p =.033); the result held after controlling for classic cardiovascular risk factors. Adjusted mean CRP levels across exhaustion strata in GA (N = 70) and AA (N = 3) carriers combined were 0.91 mg/l (none), 1.78 mg/l (moderate), and 2.61 mg/l (severe) as compared with 1.24 mg/l, 1.61 mg/l, and 1.36 mg/l for the GG wild-type (N = 202). CONCLUSION: The findings suggest that the A allele of the TNF-alpha -308 G/A polymorphism may mediate inflammation with exhaustion in a dose-response relationship, while with the GG wild-type exhaustion severity seems unrelated to CRP levels. The finding provides a rationale for gene-environmental interactions by which psychosocial factors may promote atherosclerosis and CAD
Allele · Biology · C-reactive protein · Coronary artery disease · Gene · Inflammation · Polymorphism (computer science) · Tumor necrosis factor alpha · Adipokines, Inflammation, and Metabolic Diseases · Endocrinology · Exercise and Physiological Responses · Genetics · Internal Medicine · Medicine · Stress Responses and Cortisol
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Central Nervous System Serotonin Function and Cardiovascular Responses to Stress
Relationship of Blood Coagulation and Fibrinolysis to Vital Exhaustion
Vital exhaustion predicts new cardiac events after successful coronary angioplasty
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Depressive Symptomatology and Vital Exhaustion Are Differentially Related to Behavioral Risk Factors for Coronary Artery Disease
Health behaviors, social networks, and healthy aging
| Unique citing works | 3 |
|---|---|
| Citations per year | 0.15 |
| Citation span | 2006 - 2007 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 3 |