C677T polymorphism of the MTHFR gene and variant hemoglobins
A study in newborns from Salvador, Bahia, Brazil
Bibliographic Data
| ID | 21057261 |
|---|---|
| Authors | Fábio David Couto (0000-0002-7945-4587, Fundação Oswaldo Cruz), Elisângela Vitória Adorno (Fundação Oswaldo Cruz, Brasil; Universidade Federal da Bahia, Brasil), Joelma Figueiredo Menezes (0000-0003-3978-6576, Fundação Oswaldo Cruz), José Pereira De Moura Neto (0000-0003-2177-7292, Fundação Oswaldo Cruz), Marco Antônio Vasconcelos Rêgo (0000-0001-8206-7353, Universidade Federal da Bahia), Matheus G Reis (0000-0002-3051-9060, Fundação Oswaldo Cruz), Mitermayer Galvão Dos Reis (Fundação Oswaldo Cruz), Marilda de Souza Gonçalves (0000-0003-3000-1437, Universidade Federal da Bahia) |
| Year | 2004 |
| Volume | 20 |
| Issue | 2 |
| Pages | 529-533 |
| Publication date | 2004-04-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cadernos de Saude Publica (JOURNAL) |
| Journal identifiers | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/s0102-311x2004000200021 |
| PMID | 15073633 |
| OpenAlex | W2015577853 |
| SCIELO_PID | S0102-311X2004000200021 |
| Language | EN |
| Citations received | 1 |
| References cited | 24 |
The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an increase in total homocysteine serum levels (tHcy), described as a risk factor for cardiovascular disease. Eight hundred forty-three neonates from two different maternity hospitals, one public and another private, in Salvador, Bahia, Brazil were screened for this polymorphism by PCR and RFLP. The T-allele frequency in the total sample was 0.23, and the prevalence rates of heterozygous and homozygous carriers were 36.2% and 5.3%, respectively. The T-allele frequency differed and the T/T genotype was more prevalent at the private maternity hospital. The hemoglobin (Hb) profile was investigated by HPLC in 763 newborns. The frequency of variant Hb was higher at the public than at the private maternity hospital. The association of the C677T polymorphism and the Hb profile was investigated in 683 newborns, showing a relatively high frequency of variant Hbs and the T allele. These data could provide an important basis for further studies focusing on potential risks of vaso-occlusive events in these individuals
Allele · Allele frequency · Biology · Gene · Gene polymorphism · Genotype · Homocysteine · Methylenetetrahydrofolate reductase · Polymorphism (computer science) · Folate and B Vitamins Research · Gastroenterology · Genetics · Internal Medicine · Iron Metabolism and Disorders · Medicine · Pregnancy and preeclampsia studies
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,05 |
| Citation span | 2007 - 2007 (1) |
| Citation velocity | historical |
| Highly cited | No |