Chenopodium quinoa Willd. inhibits epithelial-mesenchymal transition and slows down gastric precancerous lesions via TGF-β/Smad pathway

Bibliographic Data

ID21295771
AuthorsYansheng Wang (0009-0007-3496-8676, Tianjin University of Traditional Chinese Medicine State Key Laboratory of Component-Based Chinese Medicine), Lifei Luo (0000-0001-6606-622X, Tianjin University of Traditional Chinese Medicine State Key Laboratory of Component-Based Chinese Medicine), Meng Zhang (0000-0002-4822-2273, Tianjin University of Traditional Chinese Medicine State Key Laboratory of Component-Based Chinese Medicine), Yanmin Zhao (0000-0002-2399-9780, Logistics University of People's Armed Police Force), Yan Zha (0000-0002-8713-1665, Logistics University of People's Armed Police Force), Jingze Zhang (0000-0001-8604-8280, Tianjin University of Traditional Chinese Medicine State Key Laboratory of Component-Based Chinese Medicine), Dailin Liu (0000-0002-6400-4604, Tianjin University of Traditional Chinese Medicine State Key Laboratory of Component-Based Chinese Medicine)
Year2025
Volume127
Issue8
Pages2759-2776
Publication date2025-07-30
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueBritish Food Journal (JOURNAL)
Journal identifiersISSN: 0007-070X • E-ISSN: 1758-4108
PublisherEmerald (PUBLISHER)
DOI10.1108/bfj-07-2024-0721
OpenAlexW4411154242
LanguageEN
References cited37

Purpose The aim of this study was to investigate the cytokine, protein expression and pathway alterations of quinoa water extract (QWE) in precancerous lesions of gastric carcinoma (PLGC), and to provide new insights into the targets and mechanisms related to quinoa inhibition of PLGC. Design/methodology/approach In this study, we used drinking N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), eating disorders and intragastric administration of 40% ethanol to establish a rat PLGC model, and detected the gastric mucosal state, serum PGI and PGII levels and TGF-β1, E-cadherin, N-cadherin, Vimentin, Snail and p-Smad2/3 protein levels in the gastric tissue of rats after administration of QWE. At the same time, we used MNNG to induce GES-1 cells into MC cells, and detected the cell activity, migration ability and TGF-β1, E-cadherin, N-cadherin, Vimentin, Snail and p-Smad2/3 protein levels of the cells after administration of QWE. Findings The results demonstrated that QWE could protect the tissue structure of gastric mucosa from damage; inhibit the proliferation, migration and invasion of MC cells, promote their apoptosis and inhibit the occurrence of epithelial mesenchymal transformation by regulating the TGF-β1/Smad2/3 pathway. Originality/value In this study, it is clear that cereal quinoa has a protective effect on people with inflammatory diseases in the stomach from the perspective of dietary prevention, and provides a dietary supplement to prevent PLGC

Biology · Botany · Cancer · Chenopodium quinoa · Epithelial–mesenchymal transition · Gastric carcinoma · Metastasis · SMAD · Transforming growth factor · Cancer Research · Cell Biology · Digestive system and related health · Genetic factors in colorectal cancer · Internal Medicine · Medicine

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