Neural sensitivity to peer feedback and depression symptoms in adolescents

A 2‐year multiwave longitudinal study

Bibliographic Data

ID21344396
AuthorsDavid Pagliaccio (0000-0002-1214-1965, New York State Psychiatric Institute New York NY USA, corresponding author), Poornima Kumar (0000-0002-5851-1319, Center for Depression, Anxiety and Stress Research McLean Hospital Belmont MA USA), Rahil A Kamath (New York State Psychiatric Institute New York NY USA), Diego A Pizzagalli (0000-0002-7772-1143, Center for Depression, Anxiety and Stress Research McLean Hospital Belmont MA USA), Randy P Auerbach (0000-0003-2319-4744, New York State Psychiatric Institute New York NY USA)
Year2023
Volume64
Issue2
Pages254-264
Publication date2023-02-01
Open AccessYes
TypeARTICLE
VenueJournal of Child Psychology and Psychiatry (JOURNAL)
Journal identifiersISSN: 0021-9630 • E-ISSN: 1469-7610
PublisherWiley (PUBLISHER • GB)
DOI10.1111/jcpp.13690
PMID36082818
OpenAlexW4295027264
LanguageEN
Citations received1
References cited62

BACKGROUND: Depression risk increases during adolescent development, and individual differences in neural sensitivity to peer feedback (rejection vs. acceptance) may be a key diathesis in understanding stress-related depression risk. METHODS: At baseline, adolescents (12-14 years old; N = 124) completed clinical interviews and self-report symptom measures, and the Chatroom Task while MRI data were acquired. The majority of participants provided usable MRI data (N = 90; 76% female), which included adolescents with no maternal depression history (low risk n = 64) and those with a maternal depression history (high risk n = 26). Whole-brain regression models probed group differences in neural sensitivity following peer feedback, and whole-brain linear mixed-effects models examined neural sensitivity to peer feedback by peer stress interactions relating to depression symptoms at up to nine longitudinal assessments over 2 years. RESULTS: Whole-brain cluster-corrected results indicated brain activation moderating the strong positive association between peer interpersonal stress and depression over time. This included activation in the anterior insula, cingulate, amygdala, and striatum during anticipation and receipt of feedback (i.e., rejection vs. acceptance). Moderation effects were stronger when examining peer interpersonal (vs. non-interpersonal) stress and in relation to depression (vs. social anxiety) symptoms. CONCLUSIONS: Neural responses to peer feedback in key social and incentive processing brain regions may reflect core dispositional risk factors that interact with peer interpersonal stressors to predict adolescent depression symptom severity over time

Depression (economics) · Developmental psychology · Longitudinal study · Psychiatry · Sensitivity (control systems) · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology

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