Early childhood general anesthesia and risk of Attention Deficit Hyperactivity Disorder

Dados Bibliográficos

ID21344447
AutoresMingyang Sun (0000-0002-5790-5025, Department of Anesthesiology and Perioperative Medicine People's Hospital of Zhengzhou University, Henan Provincial People's Hospital Zhengzhou China), Wan‐Ming Chen (0009-0009-6628-0635, Graduate Institute of Business Administration, College of Management Fu Jen Catholic University Taipei Taiwan), Saihao Fu (0000-0002-0076-4102, Department of Anesthesiology and Perioperative Medicine People's Hospital of Zhengzhou University, Henan Provincial People's Hospital Zhengzhou China), Szu‐Yuan Wu (0000-0001-5637-558X, Graduate Institute of Business Administration, College of Management Fu Jen Catholic University Taipei Taiwan, autor correspondente), Jiaqiang Zhang (0000-0002-4165-0312, Department of Anesthesiology and Perioperative Medicine People's Hospital of Zhengzhou University, Henan Provincial People's Hospital Zhengzhou China, autor correspondente)
Ano2024
Volume65
Fascículo2
Páginas165-175
Data de publicação2024-02-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Child Psychology and Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 0021-9630 • E-ISSN: 1469-7610
EditoraWiley (PUBLISHER • GB)
DOI10.1111/jcpp.13871
PMID37537781
OpenAlexW4385563557
IdiomaEN
Referências citadas36

BACKGROUND: The relationship between early childhood exposure to general anesthesia (GA) and the risk of developing Attention Deficit Hyperactivity Disorder (ADHD) is still uncertain and previous studies have presented conflicting results. This population-based cohort study aimed to investigate the potential relationship between GA exposure and ADHD risk using propensity score matching (PSM) in a large sample size. METHODS: The study included 15,072 children aged 0-3 years who received GA and were hospitalized for more than 1 day in Taiwan from 2004 to 2014. The nonexposed group was randomly selected through 1:1 PSM from the Taiwan Maternal and Child Health Database (TMCHD). The primary objectives of this study were to determine the incidence rates (IR) and incidence rate ratios (IRR) of ADHD in the two cohorts, employing Poisson regression models. RESULTS: The GA group and non-GA group each comprised 7,536 patients. The IR of ADHD was higher in the GA group (122.45 per 10,000 person-years) than in the non-GA group (64.15 per 10,000 person-years), and the IRR of ADHD in the GA group was 1.39 (95% CI: 1.26, 1.55). The study found that the number of times of exposure to GA, duration of exposure, male gender, and central nervous system surgery were significant risk factors for ADHD in the future. CONCLUSIONS: This study's findings suggest that there is a significant correlation between early childhood exposure to GA and the risk of developing ADHD, and GA may be an important risk factor for ADHD in children undergoing surgery. The study also identified several risk factors for ADHD, including the number of times of exposure to GA, duration of exposure, male gender, and central nervous system surgery

Attention deficit · Attention deficit disorder · Developmental psychology · Psychiatry · Anesthesia and Neurotoxicity Research · Attention Deficit Hyperactivity Disorder · Cardiac, Anesthesia and Surgical Outcomes · Clinical Psychology · Intensive Care Unit Cognitive Disorders · Psychology