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The impact of pre-admission care on hospital mortality

Results of an instrumental variable analysis from Italy

Bibliographic Data

ID21467894
AuthorsF Moscone (0000-0001-5378-680X, Brunel University of London, corresponding author), E Tosetti (0000-0003-0979-2828, University of Padua), G Vittadini (0000-0002-0375-9763, University of Milano-Bicocca)
Year2026
Volume164
Pages105483
Publication date2026-02-01
Open AccessYes
TypeARTICLE
VenueHealth Policy (JOURNAL)
Journal identifiersISSN: 0168-8510 • E-ISSN: 1872-6054
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.healthpol.2025.105483
PMID41385893
OpenAlexW4416428068
LanguageEN
References cited6

We investigate the impact of health care spending on hospital mortality • Data on 96,778 patients admitted for acute myocardial infarction in 2007 2022 in Italy • Combined with pre-admission expenditure on pharmaceuticals and out patient visits • IV to evaluate the effect of prescriptions and outpatient expenditure on mortality • Pre-admission pharmaceutical spending significantly reduces hospital mor tality With healthcare spending projected to increase in the coming decades, the relationship between expenditure and health outcomes demands urgent attention. This paper investigates the impact of health care spending on hospital mortality. We use data on 96,778 patients admitted for acute myocardial infarction (AMI) in the Lombardy region, Italy, in the years from 2007 to 2022 and combine them with information on expenditure on pharmaceuticals and outpatient visits made in the 12 months prior to hospital admission. We adopt an instrumental variables approach to evaluate the causal impact of the total cost for pre-admission prescriptions and outpatient visits on hospital patient’s mortality. We find that pre-admission healthcare, particularly pharmaceutical spending, has a significant impact on reducing mortality rates within hospitals, with a 10% increase in pharmaceutical spending leading to a reduction in mortality by around 3.0 percentage points, although this result varies depending on the age group and the type of infarction. The findings suggest that prioritizing pharmaceutical management can significantly reduce hospital mortality, highlighting a key area for healthcare optimization

Health care · Healthcare system · Hospital care · Instrumental variable · Advanced Causal Inference Techniques · Health Systems, Economic Evaluations, Quality of Life · Healthcare Policy and Management

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Highly citedNo
Open DOIOpen Access
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