Fiber burden and asbestos-related diseases
An umbrella review
Bibliographic Data
| ID | 21481852 |
|---|---|
| Authors | J M Ramada (0000-0002-3854-1596, Parc de Salut, corresponding author), José María Ramada Rodilla, Beatriz Calvo Cerrada, Beatriz Calvo-Cerrada (0000-0001-8052-3319, Parc de Salut), Consol Serra Pujadas (Parc de Salut), George L Delclos (0000-0003-0201-8135, Southwest Center for Educational Excellence), Fernando G Benavides (0000-0003-0747-2660, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) |
| Year | 2022 |
| Volume | 36 |
| Issue | 2 |
| Pages | 173-183 |
| Publication date | 2022-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Gaceta Sanitaria (JOURNAL) |
| Journal identifiers | ISSN: 0213-9111 • E-ISSN: 1578-1283 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.gaceta.2021.04.001 |
| PMID | 34120777 |
| OpenAlex | W3169983245 |
| Language | EN |
| Citations received | 1 |
| References cited | 22 |
OBJECTIVE: What are the levels of asbestos exposure that cause each type of health effect? The objective of this study was to review the available scientific evidence on exposure levels for asbestos and their relationship to health effects. METHOD: An umbrella review of English-language reviews and meta-analyses, from 1980 to March 2021 was conducted. We included reviews involving quantified asbestos exposures and health outcomes. The review has been adapted to the indications of the PRISMA declaration. Methodological quality of the selected studies was assessed using the AMSTAR instrument. RESULTS: We retrieved 196 references. After applying the search strategy and quality analysis, 10 reviews were selected for in-depth analysis. For lung cancer, the highest risk was observed with exposure to amphiboles. Longer, thinner fibers had the greatest capacity to cause lung cancer, especially those > 10 μm in length. For mesothelioma, longer and thinner fibers were also more pathogenic; amphiboles ≥ 5 μm are especially associated with increased mesothelioma risk. No studies observed an increased risk for lung cancer or mesothelioma at asbestos exposure levels <0.1 f/ml. No reviews provided information on exposure concentrations for pulmonary fibrosis. Currently, there is limited evidence in humans to establish the causal relationship between gastrointestinal cancer and asbestos exposure. CONCLUSIONS: Banning all asbestos exposure remains the best measure to preventing its negative health effects. The highest quality reviews and meta-analyses support that there is little risk of lung cancer or mesothelioma at daily exposure levels below 0.1 f/ml
Asbestos · Asbestos fibers · Composite material · Environmental health · Fiber · MEDLINE · Air Quality and Health Impacts · Chemistry · Materials Science · Medicine · Multiple and Secondary Primary Cancers · Occupational and environmental lung diseases
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |