The total triterpenoid extract of Prunella vulgaris exerts anti-inflammatory effects by suppressing the NF-κB/TLR/TNF-α signaling axis in Lipopolysaccharide-stimulated RAW264.7 cells
Bibliographic Data
| ID | 21544071 |
|---|---|
| Authors | Zhimei Hu (Hubei University of Chinese Medicine), Lei Xu (0009-0000-3744-0753, Hubei University of Chinese Medicine), Zhonghua Du (0000-0002-8673-5926, Hubei University of Chinese Medicine), Junjie Hu (0000-0003-3557-0452, Hubei University of Chinese Medicine), Yan Meng (0000-0002-0614-8968, Hubei University of Chinese Medicine), Shilei Wang (0000-0003-3162-8231, Hubei University of Chinese Medicine), Lichun Ye (Hubei University of Chinese Medicine, corresponding author), Zhaohua Shi (0000-0002-4640-5076, Hubei University of Chinese Medicine, corresponding author) |
| Year | 2026 |
| Volume | 356 |
| Pages | 120778 |
| Publication date | 2026-02-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.120778 |
| PMID | 41139040 |
| OpenAlex | W4415459654 |
| Language | EN |
| References cited | 48 |
This study provides a green and efficient extraction and purification process for PVTH. Through this process, PVTH with a purity of 65.42 % was prepared. Additionally, the study analyzed the composition of PVTH and conducted an in-depth investigation into its anti-inflammatory activity, mechanism of action, and in vivo anti-inflammatory efficacy. These results highlight the therapeutic potential of PVTH in inflammatory diseases and provide a basis for further research on P. vulgaris L. in fields such as cosmetics and functional foods
Cosmetics · Cytotoxicity · Extraction (chemistry) · Folk medicine · In vivo · Pharmacognosy · Prunella vulgaris · Triterpenoid · Biological Activity of Diterpenoids and Biflavonoids · Natural product bioactivities and synthesis · Pharmacological Effects of Natural Compounds · Plant Toxicity and Pharmacological Properties
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| Citation velocity | historical |
|---|---|
| Highly cited | No |