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Identification of potential biomarkers for Polygonum multiflorum–induced liver injury in a clinical cohort

Integrating machine learning of metabolomics with transcriptomic profiling

Bibliographic Data

ID21544072
AuthorsChao Lei (0000-0001-9091-2449), C Z Lei (Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author), Meng Qiao (0000-0002-6019-5896, Chinese Academy of Medical Sciences & Peking Union Medical College), Chaoren Tan (Chinese Academy of Medical Sciences & Peking Union Medical College), Erjun Gao (Taiyuan Institute of Technology), Wenliang Lv (Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author), Yanming Xie (0009-0000-0823-2226, Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author), Zheng Wang (0000-0003-0758-2202, Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author), Zhifei Wang (0000-0002-6680-2618)
Year2026
Volume366
Pages121618
Publication date2026-07-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121618
PMID41933744
OpenAlexW7147565553
LanguageEN
References cited53

Biomarker discovery · Feature selection · Metabolome · Metabolomics · Profiling (computer programming) · Random forest · Support vector machine · Transcriptome · Drug-Induced Hepatotoxicity and Protection · Ginger and Zingiberaceae research · Phytochemistry and biological activity of medicinal plants

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    Open Access•Yinghuan Hu, Chengyu Wang et al.•Journal of Ethnopharmacology•2023

  • Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02

    Open Access•Minjiang Wang, Ronghua Zhao et al.•Journal of Ethnopharmacology•2012

  • Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells

    Open Access•Ying-huan Hu, HU Yinghuan et al.•Journal of Ethnopharmacology•2021

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