A structurally distinct neutral polysaccharide from Polygonatum odoratum (Mill.) Druce improves hyperglycemia via the PI3K-AKT-GSK3β/FoxO1 signaling pathway
Bibliographic Data
| ID | 21544086 |
|---|---|
| Authors | Lan Li (0000-0002-0408-8615, Huaihua University), Yamei Li (0000-0003-4609-501X, Hunan University of Traditional Chinese Medicine), Lan Xiao (0000-0002-1265-7494), Xiao Lan (0000-0002-4091-5569, Hunan University of Traditional Chinese Medicine), Jingchen Xie (0009-0002-8538-8878, Hunan University of Traditional Chinese Medicine), Xia Li (0000-0003-3050-8529, Hunan University of Traditional Chinese Medicine), Li Xia (0000-0003-2465-9232), Yanwen Fu (0000-0002-9394-9498, Hunan University of Traditional Chinese Medicine), Yizhi Fu, Na Li (0000-0002-1103-6864, Hunan University of Traditional Chinese Medicine), Limei Lin (0000-0002-2583-1797, Hunan University of Traditional Chinese Medicine, corresponding author), Ping Wu (0000-0002-0788-6268, Hunan University of Traditional Chinese Medicine, corresponding author), Zhimin Zhang (0000-0002-9194-7560, Hunan University of Traditional Chinese Medicine, corresponding author) |
| Year | 2026 |
| Volume | 358 |
| Pages | 120996 |
| Publication date | 2026-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.120996 |
| PMID | 41344518 |
| OpenAlex | W4416930341 |
| Language | EN |
| References cited | 57 |
Folk medicine · Glycogen · Glycosidic bond · Pharmacognosy · Polysaccharide · Signal transduction · Structure–activity relationship · Food composition and properties · Metabolism, Diabetes, and Cancer · Polysaccharides and Plant Cell Walls
Type 2 diabetes
IDF Diabetes Atlas
Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats
Antidiabetic effects of Morus alba fruit polysaccharides on high-fat diet- and streptozotocin-induced type 2 diabetes in rats
Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects
Dendrobium officinale polysaccharide ameliorates diabetic hepatic glucose metabolism via glucagon-mediated signaling pathways and modifying liver-glycogen structure
| Citation velocity | historical |
|---|---|
| Highly cited | No |