Ethical Implications in Making Use of Human Cerebral Organoids for Investigating Stress—Related Mechanisms and Disorders
Bibliographic Data
| ID | 21598167 |
|---|---|
| Authors | Katherine Bassil (0000-0002-4424-9938, Maastricht University, corresponding author), Dorothee Horstkötter (0000-0002-6046-2798, Maastricht University, corresponding author) |
| Year | 2023 |
| Volume | 32 |
| Issue | 4 |
| Pages | 529-541 |
| Publication date | 2023-10-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cambridge Quarterly of Healthcare Ethics (JOURNAL) |
| Journal identifiers | ISSN: 0963-1801 • E-ISSN: 1469-2147 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s0963180123000038 |
| PMID | 36799029 |
| OpenAlex | W4321169687 |
| Language | EN |
| Citations received | 1 |
| References cited | 60 |
The generation of three-dimensional cerebral organoids from human-induced pluripotent stem cells (hPSC) has facilitated the investigation of mechanisms underlying several neuropsychiatric disorders, including stress-related disorders, namely major depressive disorder and post-traumatic stress disorder. Generating hPSC-derived neurons, cerebral organoids, and even assembloids (or multi-organoid complexes) can facilitate research into biomarkers for stress susceptibility or resilience and may even bring about advances in personalized medicine and biomarker research for stress-related psychiatric disorders. Nevertheless, cerebral organoid research does not come without its own set of ethical considerations. With increased complexity and resemblance to in vivo conditions, discussions of increased moral status for these models are ongoing, including questions about sentience, consciousness, moral status, donor protection, and chimeras. There are, however, unique ethical considerations that arise and are worth looking into in the context of research into stress and stress-related disorders using cerebral organoids. This paper provides stress research-specific ethical considerations in the context of cerebral organoid generation and use for research purposes. The use of stress research as a case study here can help inform other practices of in vitro studies using brain models with high ethical considerations
Biology · Human brain · Organoid · Sentience · 3D Printing in Biomedical Research · Computer Science · Neuroethics, Human Enhancement, Biomedical Innovations · Neuroscience · Pluripotent Stem Cells Research · Psychology
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |