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Co-Trajectories of Substance Use and Work Status

Longitudinal Exploratory Descriptive Findings From the Constances Cohort

Bibliographic Data

ID21645147
AuthorsRita El Haddad (0000-0003-1984-277X, Université Paris Cité, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, INSERM UMS 011 « Population-based Cohorts Unit », corresponding author), Sofiane Kab (0000-0001-6041-9602, Université Paris Cité, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, INSERM UMS 011 « Population-based Cohorts Unit »), Pierre Meneton (0000-0003-4611-1892, INSERM U1142 LIMICS, UMRS 1142, Sorbonne Universities, UPMC University of Paris 06, University of Paris 13), Marie Zins (0000-0002-4540-4282, Université Paris Cité, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, INSERM UMS 011 « Population-based Cohorts Unit »), Emmanuel Wiernik (0000-0001-8046-7919, Université Paris Cité, Paris Saclay University, Université de Versailles Saint-Quentin-en-Yvelines, INSERM UMS 011 « Population-based Cohorts Unit »), Guillaume Airagnes (0000-0002-3494-5083, Population-based Epidemiological Cohorts Unit, UMS 011, INSERM, AP-HP.Centre-Université Paris Cité)
Year2026
Volume61
Issue6
Pages880-889
Publication date2026-05-12
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueSubstance Use & Misuse (JOURNAL)
Journal identifiersISSN: 1082-6084 • E-ISSN: 1532-2491
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/10826084.2025.2582767
PMID41243135
OpenAlexW4416292711
LanguageEN
References cited41

OBJECTIVE: We aimed to identify substance use and work status co-trajectories and to describe the sociodemographic and clinical characteristics of each profile. METHODS: From the French CONSTANCES cohort, 19,285 adults enrolled between 2012 and 2015, were included in the analyses. Clusters of co-trajectories of substance use (alcohol, tobacco and cannabis) and work status at baseline and 5-years period of follow-up were identified using finite mixture models. For each cluster, age, sex, indicator of social position (i.e. education, occupational grade, household monthly income and marital status) and self-rated health were described. RESULTS: Among the 12 identified clusters, participants in the cluster with the lowest non-working rate (4.3%) were at low-risk drinkers, nonsmokers and never consumed cannabis. In the cluster with the highest non-working rate (14.5%), participants were nondrinkers, smokers and consumed cannabis less than once per month. The 3 clusters with the highest non-working rates (i.e. Clusters 6, 7, 12) were characterized by fewer women overall, lower social position, poorer self-rated health, and high substance use. CONCLUSION: The present study identified different substance use and work co-trajectories underlining the heterogeneity in individual experiences with respect to these factors

Cohort · Cohort study · Exploratory research · Longitudinal study · Substance abuse · Substance use · Employment and Welfare Studies · Substance Abuse Treatment and Outcomes · Workplace Health and Well-being

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